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Sponsors and Collaborators: |
Hamilton Health Sciences Canadian Institutes of Health Research (CIHR) |
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Information provided by: | McMaster University |
ClinicalTrials.gov Identifier: | NCT00182195 |
A multinational, randomized trial comparing two lung protecting strategies of respiratory life support among critically ill patients with severe lung injury.
Condition | Intervention | Phase |
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Acute Respiratory Distress Syndrome |
Procedure: Control Ventilation Strategy |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | A Randomized Trial of a Lung-Open Ventilation Strategy in Acute Lung Injury |
Estimated Enrollment: | 980 |
Study Start Date: | August 2000 |
Study Completion Date: | March 2006 |
To compare an innovative Lung Open Ventilation strategy with a proven low tidal volume strategy, hypothesizing that the Lung Open Ventilation strategy may reduce mortality, other organ dysfunction, and the duration of mechanical ventilation, intensive care, and hospital stay.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Canada, Ontario | |
Hamilton Health Sciences - General Hospital | |
Hamilton, Ontario, Canada, L8L 5G4 |
Principal Investigator: | Maureen O Meade, MD, FRCPC | McMaster University |
Study ID Numbers: | 38141-1 |
Study First Received: | September 12, 2005 |
Last Updated: | April 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00182195 History of Changes |
Health Authority: | Canada: Health Canada |
Respiratory Tract Diseases Lung Diseases Respiration Disorders Respiratory Distress Syndrome, Adult Acute Respiratory Distress Syndrome |
Pathologic Processes Disease Respiratory Tract Diseases Lung Diseases |
Syndrome Respiration Disorders Respiratory Distress Syndrome, Adult |