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Sponsored by: |
Makerere University |
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Information provided by: | Makerere University |
ClinicalTrials.gov Identifier: | NCT00372541 |
Acute lower respiratory tract infections are a leading cause of morbidity and mortality in sub Saharan Africa. The World Health Organisation (WHO) still recommends intravenous chloramphenicol for the treatment of severe pneumonia in children aged less than five years. However, up to 20% of children fail treatment due to the emergence of resistance by bacteria. Several centers now use ceftriaxone, a third generation cephalosporin, which is reported to be efficacious in the treatment of severe pneumonia. However the high cost of ceftriaxone is too prohibitive to allow for its routine use in resource constrained countries. The purpose of this study is to compare chloramphenicol and ceftriaxone in the treatment of severe pneumonia in children under five. We hypothesize that 92.7% of children who receive once daily intravenous ceftriaxone (75 mg/kg body weight)for 7 days, will recover from severe pneumonia compared to 80.2 % of those who receive intravenous chloramphenicol (25mg/kg body weight/dose every 6 hours for 7 days).
Condition | Intervention | Phase |
---|---|---|
Pneumonia |
Drug: ceftriaxone |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Ceftriaxone Versus Chloramphenicol for Treatment of Severe Pneumonia in Children Aged Less Than Five Years at Mulago Hospital: A Randomized Controlled Trial |
Estimated Enrollment: | 348 |
Study Start Date: | September 2006 |
Estimated Study Completion Date: | June 2007 |
A recent report from the World health Organization showed pneumonia was the leading cause of death in children less than 5 years. WHO recommends intravenous Chloramphenicol 25mg/kg six hourly as the first line drug for the treatment of severe pneumonia in these children. Ceftriaxone 75mg/kg daily is the second line drug. The efficacy of chloramphenicol for the treatment of severe pneumonia ranges from 80%-84%, while that of ceftriaxone ranges from 85% to 97%. However the high cost of ceftriaxone is too prohibitive to allow for its routine use in resource constrained countries. A study comparing penicillin G plus chloramphenicol and ceftriaxone in the treatment of severe pneumonia in Turkey found that both drugs were equally effective in normalization of the outcome parameters. A recent Cochrane review found no randomized controlled trials comparing both drugs in the treatment of severe forms of pneumonia.
The objective of this study it to compare the efficacy of Ceftriaxone versus Chloramphenicol in the treatment of severe pneumonia in the children under five years of age admitted to Mulago hospital. This will be a double- blinded randomized controlled trial. Three hundred forty eight children with severe pneumonia will be randomized to receive either intravenous ceftriaxone 75mg/kg/day for seven days or intravenous chloramphenicol 100mg/kg/day for seven days. The primary outcome will mortality and secondary outcomes will be time taken to normalization of respiratory rate, temperature and oxygen saturation.
Ages Eligible for Study: | 6 Months to 59 Months |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: James Tumwine, PhD | +256 772 494120 | jtumwine@imul.com |
Contact: Grace Ndeezi, MMED | +256 772 453191 | gracendeezi@yahoo.com |
Uganda | |
Department of Paediatrics and Child Health, Makerere University | Recruiting |
Kampala, Uganda, P O 7072 | |
Principal Investigator: Cordelia M Katureebe, MBCHB | |
Department of Paediatrics and Child, Makerere University | Recruiting |
Kampala, Uganda, P O 7072 | |
Contact: James K Tumwine, PhD +256 772 494120 jtumwine@imul.com | |
Contact: Grace Ndeezi, MMED +256 772 453191 gracendeezi@yahoo.com | |
Principal Investigator: Cordelia M Katureebe, MBCHB | |
Sub-Investigator: Edson A Mworozi, MMED | |
Sub-Investigator: Kaddu Mulindwa, PhD | |
Department of paediatrics and child Health,Makerere university | Recruiting |
Kampala, Uganda, P O 7072 | |
Uganda, East Africa | |
Department of Paediatrics and Child Health, Mulago Hospital | Not yet recruiting |
Kampala, East Africa, Uganda, 256 | |
Contact: James K Tumwine, PhD +256 772 494120 jtumwine@imul.com | |
Contact: Grace Ndeezi, MMED +256 772 453191 gracendeezi@yahoo.com | |
Principal Investigator: Cordelia M Katureebe, MBCHB | |
Sub-Investigator: Edson A Mworozi, MMED | |
Sub-Investigator: Kaddu Mulindwa, MSC |
Principal Investigator: | Cordelia M Katureebe, MBCHB | Makerere University |
Study ID Numbers: | HD1120041348U |
Study First Received: | September 6, 2006 |
Last Updated: | September 13, 2006 |
ClinicalTrials.gov Identifier: | NCT00372541 History of Changes |
Health Authority: | Uganda: National Council for Science and Technology |
ceftriaxone chloramphenicol severe pneumonia children |
Anti-Bacterial Agents Chloramphenicol succinate Chloramphenicol Respiratory Tract Infections |
Respiratory Tract Diseases Lung Diseases Ceftriaxone Pneumonia |
Anti-Infective Agents Chloramphenicol Chloramphenicol succinate Molecular Mechanisms of Pharmacological Action Enzyme Inhibitors Ceftriaxone Pharmacologic Actions |
Anti-Bacterial Agents Protein Synthesis Inhibitors Respiratory Tract Diseases Respiratory Tract Infections Lung Diseases Therapeutic Uses Pneumonia |