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Sponsored by: |
National Center for Research Resources (NCRR) |
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Information provided by: | National Center for Research Resources (NCRR) |
ClinicalTrials.gov Identifier: | NCT00015626 |
The goal of this study is to aggressively treat insulin resistance and its clinical manifestations when they first appear in childhood, and to prevent the subsequent progression towards impaired glucose tolerance and type-2 diabetes. In the process of this clinical trial, we will learn more about the early manifestations of insulin resistance, its treatment, and its relationship to obesity and type-2 diabetes through parallel in-vivo and in-vitro studies.
Condition | Intervention | Phase |
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Insulin Resistance Diabetes Mellitus |
Drug: Metformin Procedure: skin biopsy Behavioral: diet and exercise Drug: pioglitazone Drug: rosiglitazone |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Efficacy Study |
Official Title: | A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes) |
Ages Eligible for Study: | 5 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
Exclusion Criteria:
Study ID Numbers: | NCRR-M01RR06020-0057 |
Study First Received: | April 24, 2001 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00015626 History of Changes |
Health Authority: | United States: Federal Government |
Metabolic Diseases Pioglitazone Metformin Diabetes Mellitus Endocrine System Diseases Insulin Hyperinsulinism |
Hypoglycemic Agents Diabetes Mellitus, Type 2 Insulin Resistance Endocrinopathy Glucose Metabolism Disorders Metabolic Disorder Rosiglitazone |
Hyperinsulinism Hypoglycemic Agents Metabolic Diseases Pioglitazone Physiological Effects of Drugs Diabetes Mellitus, Type 2 |
Diabetes Mellitus Endocrine System Diseases Insulin Resistance Glucose Metabolism Disorders Rosiglitazone Pharmacologic Actions |