Study of Arthritis and Related Conditions - Full Text View

Sponsored by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00006333

Purpose

The purpose of this study is to learn more about the causes of rheumatoid arthritis, juvenile rheumatoid arthritis and related conditions and the course of these diseases. Patients in this study will not receive treatment, but may be offered participation in a treatment protocol if an appropriate study is available.

Children and adults of all ages with known or suspected arthritis are eligible for this study. Participants will undergo the following tests and procedures:

Medical history and physical examination
Measurements of weight and height
Blood sample collections for clinical and research purposes
X-rays of hand, feet or other affected joints, if x-rays have not been taken in the past 3 months and are medically indicated
Magnetic resonance imaging (in some patients) to assess disease or study the usefulness of this diagnostic method for arthritis patients
Quality of life questionnaires
Stride analyzer test (children only) - computer system analysis of walking speed and pattern
Hand functional test (children only) - detailed study of hand function
Walk/run time (children only) - measurement of distance the child can walk or run in 9 minutes (heart rate and blood pressure are taken before and after the test)
Synovial biopsy (in some patients) - removal of a sample of tissue from the synovium (lining of the joint) for evaluation under the microscope. The procedure is done under local anesthetic.

Condition
Arthritis Synovitis

MedlinePlus related topics: Juvenile Rheumatoid Arthritis Rheumatoid Arthritis

U.S. FDA Resources

Study Type:	Observational
Official Title:	Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions

Further study details as provided by National Institutes of Health Clinical Center (CC):

Study Start Date:

September 2000

Detailed Description:

This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

INCLUSION CRITERIA:

No age limits.

History of inflammatory synovitis of at least one or more swollen joints.

Patient's ability and willingness to give informed consent or in the pediatric patients, the parent's willingness to give informed consent and the patient's willingness to assent to the protocol whenever possible.

EXCLUSION CRITERIA:

None if patients fulfill inclusion criteria.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00006333

Contacts

Contact: Patient Recruitment and Public Liaison Office	(800) 411-1222	prpl@mail.cc.nih.gov
Contact: TTY	1-866-411-1010

Locations

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike	Recruiting
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

More Information

Additional Information:

NIH Clinical Center Detailed Web Page This link exits the ClinicalTrials.gov site

Publications:

Lin JP, Cash JM, Doyle SZ, Peden S, Kanik K, Amos CI, Bale SJ, Wilder RL. Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet. 1998 Oct;103(4):475-82.

Case JP, Lafyatis R, Remmers EF, Kumkumian GK, Wilder RL. Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am J Pathol. 1989 Dec;135(6):1055-64.

Glass DN, Giannini EH. Juvenile rheumatoid arthritis as a complex genetic trait. Arthritis Rheum. 1999 Nov;42(11):2261-8. Review. No abstract available.

Study ID Numbers:	000222, 00-AR-0222
Study First Received:	October 4, 2000
Last Updated:	July 19, 2008
ClinicalTrials.gov Identifier:	NCT00006333 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Rheumatoid Arthritis
Inflammation
Synovitis
Genetics
Synovial Biopsy

Arthritis
Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis
Juvenile Rheumatoid Arthritis
JRA

Study placed in the following topic categories:

Arthritis, Juvenile Rheumatoid
Musculoskeletal Diseases
Joint Diseases
Arthritis

Arthritis, Rheumatoid
Synovitis
Inflammation

Additional relevant MeSH terms:

Musculoskeletal Diseases
Joint Diseases
Arthritis
Synovitis

ClinicalTrials.gov processed this record on May 06, 2009