Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases

This study is currently recruiting participants.

Verified by University of Heidelberg, October 2003

First Received: September 14, 2005 Last Updated: March 9, 2006 History of Changes

Sponsored by:	University of Heidelberg
Information provided by:	University of Heidelberg
ClinicalTrials.gov Identifier:	NCT00221832

Purpose

The aim of this study is the identification of familial congenital arrhythmogenic disorders and their clinical follow-up.

Condition
Long QT Syndrome Hypertrophic Cardiomyopathy Arrhythmogenic Right Ventricular Dysplasia

Genetics Home Reference related topics: Andersen-Tawil syndrome Brugada syndrome Jervell and Lange-Nielsen syndrome Romano-Ward syndrome short QT syndrome

MedlinePlus related topics: Cardiomyopathy Genetic Testing

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study

Further study details as provided by University of Heidelberg:

Estimated Enrollment:	300
Study Start Date:	October 2003
Estimated Study Completion Date:	December 2008

Detailed Description:

Molecular genetic screening in patients with:

supraventricular
ventricular arrhythmia
syncopes of unknown origin and/or suspicion of an arrhythmogenic origin
family members of patients with sudden cardiac death and aborted sudden cardiac death

Examination of patients includes routine testing like electrocardiogram (ECG), sequential ECGs, exercise testing, invasive electrophysiological stimulation, cardiac magnetic resonance imaging, intravenous drug challenge for identification/exclusion of eg Brugada syndrome. Examples are patients with Long QT Syndrome, Short QT Syndrome, Brugada Syndrome, familial atrial fibrillation, WPW-syndrome, arrhythmias due to familial hypertrophic cardiomyopathy or arrhythmogenic right ventricular dysplasia. Blood samples are taken for further molecular genetic screening.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients with a history of syncope, abnormal ECG and suspicion of an arrhythmogenic disease
Patients with long QT syndrome
Patients with short QT syndrome, shortened QT intervals, borderline shortened QT intervals
Patients with Brugada syndrome
Patients with hypertrophic cardiomyopathy
Patients with arrhythmogenic right ventricular dysplasia

Exclusion Criteria:

Inability to understand study protocol

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00221832

Contacts

Contact: Christian Wolpert, MD	+49-621-383-2206	christian.wolpert@med.ma.uni-heidelberg.de
Contact: Rainer Schimpf, MD	+49-621-383-2206	rainer.schimpf@med.ma.uni-heidelberg.de

Locations

Germany
University Hospital Mannheim, I. Department of Medicine	Recruiting
Mannheim, Germany, 68167
Contact: Christian Wolpert, MD +49-621-3832206 christian.wolpert@med.ma.uni-heidelberg.de
Contact: Rainer Schimpf, MD +49-621-3832206 rainer.schimpf@med.ma.uni-heidelberg.de
Principal Investigator: Christian Wolpert, MD

Sponsors and Collaborators

University of Heidelberg

Investigators

Study Director:

Martin Borggrefe, Prof., MD

I. Department of Medicine-Cardiology

More Information

No publications provided

Study ID Numbers:	0261.5
Study First Received:	September 14, 2005
Last Updated:	March 9, 2006
ClinicalTrials.gov Identifier:	NCT00221832 History of Changes
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Heidelberg:

Long QT Syndrome
Hypertrophic cardiomyopathy
arrhythmogenic right ventricular dysplasia
Short QT Syndrome
Brugada Syndrome

Study placed in the following topic categories:

Pathological Conditions, Anatomical
Heart Diseases
Cardiovascular Abnormalities
Constriction, Pathologic
Cardiomyopathies
Heart Valve Diseases
Hypertrophy
Cardiomyopathy, Hypertrophic

Brugada Syndrome
Long QT Syndrome
Congenital Abnormalities
Aortic Valve Stenosis
Heart Defects, Congenital
Arrhythmogenic Right Ventricular Dysplasia
Arrhythmias, Cardiac

Additional relevant MeSH terms:

Pathological Conditions, Anatomical
Disease
Heart Diseases
Cardiovascular Abnormalities
Cardiomyopathies
Heart Valve Diseases
Hypertrophy
Pathologic Processes
Aortic Stenosis, Subvalvular

Cardiomyopathy, Hypertrophic
Syndrome
Long QT Syndrome
Cardiovascular Diseases
Congenital Abnormalities
Aortic Valve Stenosis
Heart Defects, Congenital
Arrhythmogenic Right Ventricular Dysplasia
Arrhythmias, Cardiac

ClinicalTrials.gov processed this record on May 06, 2009