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Sponsored by: |
National Institute of Environmental Health Sciences (NIEHS) |
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Information provided by: | National Institute of Environmental Health Sciences (NIEHS) |
ClinicalTrials.gov Identifier: | NCT00468663 |
An epidemiologic study of pregnant women in western Washington to measure the relationships between exposure to air pollutants and risks of preeclampsia and preterm delivery.
Condition |
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Preeclampsia Preterm Delivery |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Official Title: | Ambient Air Pollution, Preeclampsia, and Preterm Delivery |
Enrollment: | 4200 |
Study Start Date: | July 2006 |
We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures during and before pregnancy.
We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure.
Ages Eligible for Study: | 18 Years and older |
Inclusion Criteria:
Exclusion Criteria:
-
Study ID Numbers: | 14716-CP-001 |
Study First Received: | May 2, 2007 |
Last Updated: | May 2, 2007 |
ClinicalTrials.gov Identifier: | NCT00468663 History of Changes |
Health Authority: | United States: Federal Government |
preeclampsia preterm delivery lipid peroxidation inflammation |
Hypertension, Pregnancy-Induced Pregnancy Complications Eclampsia Obstetric Labor, Premature Obstetric Labor Complications |
Pre-Eclampsia Preeclampsia Hypertension Inflammation Premature Birth |
Hypertension, Pregnancy-Induced Pregnancy Complications Obstetric Labor, Premature |
Obstetric Labor Complications Pre-Eclampsia Premature Birth |