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Sponsored by: |
Maastricht University Medical Center |
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Information provided by: | Maastricht University Medical Center |
ClinicalTrials.gov Identifier: | NCT00468507 |
Patients undergoing major surgery, trauma and burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently our group demonstrated that administration of high fat feeding prior to hemorrhagic shock attenuates severe inflammation, gut barrier loss and hepatic damage. High fat feeding releases cholecystokinin in the gut, which stimulates the autonomous nervous system and subsequently activates the efferent vagus nerve. The activated efferent fibers inhibit tissue macrophages via binding of acetylcholine to the alpha7-nicotinergic receptor. In this study the cholecystokinin release in healthy volunteers is monitored in response to low fat and high fat food products.
Condition | Intervention | Phase |
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Trauma |
Dietary Supplement: nutritional intervention with Respifor and Diasip |
Phase 0 |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator), Active Control, Crossover Assignment |
Official Title: | The Anti-Inflammatory Effects of High-Fat Nutrition; Towards a Clinical Application |
Estimated Enrollment: | 24 |
Study Start Date: | March 2007 |
Estimated Study Completion Date: | March 2009 |
Estimated Primary Completion Date: | September 2008 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 45 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Tim Lubbers, PhD-student | 0433882128 ext 0031 | t.lubbers@ah.unimaas.nl |
Netherlands, Limburg | |
University Maastricht | Recruiting |
Maastricht, Limburg, Netherlands, 6200 MD |
Principal Investigator: | Jan-Willem Greve, professor | Maastricht University Medical Center |
Responsible Party: | Maastricht University Medical Center ( J.W.M. Greve, MD, PhD ) |
Study ID Numbers: | 067030 |
Study First Received: | May 1, 2007 |
Last Updated: | May 5, 2009 |
ClinicalTrials.gov Identifier: | NCT00468507 History of Changes |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
CCK release |
Wounds and Injuries |