DISEASE CHARACTERISTICS:

• Histologically confirmed B-cell lymphoma

  • Eligible subtypes:

    • Intermediate or high-grade non-Hodgkin's lymphoma (NHL), defined as follicular large cell, mantle cell, diffuse mixed cell, diffuse large cell and variants, Burkitt or Burkitt-like, or unclassifiable aggressive histologies
    • Body cavity-based lymphoma or primary effusion lymphoma
• Evidence of HIV infection

• Received at least 1 prior systemic chemotherapy regimen with failure to respond or relapse after completion of first-line therapy, including one of the following doxorubicin-based combinations:

  • Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)
  • Infusional cyclophosphamide, doxorubicin, and etoposide (CDE)
  • Etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (EPOCH)
• Evaluable disease outside of prior radiation port
• No CNS parenchymal or leptomeningeal involvement
• No primary CNS NHL
• No HTLV-1-associated leukemia or lymphoma NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the terminology of "low", "intermediate", or "high" grade lymphoma.

However,this protocol uses the former terminology.

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• Karnofsky 70-100%

Life expectancy:

• At least 12 weeks

Hematopoietic:

• Absolute granulocyte count at least 1,000/mm3
• Platelet count at least 75,000/mm3
• Hemoglobin at least 8.0 g/dL

Hepatic:

• Bilirubin no greater than 1.5 mg/dL (unless concurrently on indinavir)
• SGOT and SGPT less than 3 times upper limit of normal

Renal:

• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance at least 50 mL/min

Cardiovascular:

• No history of cardiac disease
• LVEF at least 45% by radionuclide ventriculography
• No symptomatic congestive heart failure
• No active angina pectoris
• No uncontrolled hypertension

Pulmonary:

• No history of symptomatic pulmonary disease
• Corrected DLCO more than 50% predicted
• No severe chronic obstructive lung disease
• No symptomatic restrictive lung disease

Other:

• Recurrent controllable infection (e.g., thrush) on chronic suppressive therapy allowed
• No active uncontrolled infection
• No active significant opportunistic infection (e.g., acute Pneumocystis pneumonia, cytomegalovirus retinitis on induction or maintenance therapy, acute toxoplasmosis)
• No grade 2 or greater peripheral neuropathy
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• At least 24 hours since prior transfusion
• At least 24 hours since prior colony-stimulating factor therapy
• No concurrent prophylactic filgrastim (G-CSF)

Chemotherapy:

• See Disease Characteristics
• No concurrent hydroxyurea

Endocrine therapy:

• Not specified

Radiotherapy:

• See Disease Characteristics
• At least 4 weeks since prior large-field radiotherapy

Surgery:

• Not specified

Other:

• At least 3 weeks since prior anticancer therapy and recovered
• Must be receiving stable antiretroviral regimen of at least 4 weeks duration