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Sponsors and Collaborators: |
Ullevaal University Hospital Schering-Plough |
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Information provided by: | Ullevaal University Hospital |
ClinicalTrials.gov Identifier: | NCT00308048 |
Patients with HCV genotype 2 or 3 infection who have a rapid virological response to treatment are randomised to either 14 or 24 weeks HCV treatment. Our hypothesis is that there is no important difference in effect between the two treatment effect.
Condition | Intervention | Phase |
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Hepatitis C Virus Infection |
Drug: Pegylated Interferon alfa 2b and ribavirin |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | 14 Vs 24 Weeks HCV Treatment to Genotype 2/3 Patients With Rapid Virological Response |
Estimated Enrollment: | 435 |
Study Start Date: | March 2004 |
Estimated Study Completion Date: | September 2006 |
Patients with HCV genotype 2 or 3 infection are currently recommended 6 months treatment with pegylated interferon alfa (2a or 2b) and ribavirin.Approximately 80% obtain sustained virological response (HCV RNA undetectable 6 months after treatment) to this approach. However, the treatment is associated with many and sometimes serious side effects. In addition, the treatment is costly also in econimical terms. Increasing the treatment duration beyond 6 months does not increase the response rate. Shorter treatment has only been assessed in small trials, but the results have been encouraging. In this randomised, open label,multicenter phase 3 trial with acitive controls patients are treated with pegylated interferon alfa 2a (PegIntron (R), Schering Plough NJ)(1,5 mcg/kg)and ribavirin (Rebetol (R), Schering Plough, NJ) (800-1400mg based on weight)for 4 weeks. Those who are HCV RNA negative at week 4 (<50 IU; Cobas Amplicor Monitor Test, Roche Diagnostic) are defined as rapid virological responders and randomised to either an additional 10 or 20 weeks combination treatment. Patients who are HCV RNA positive are all treated for 20 more weeks. The endpoint is sustained virological response defined as undetectable HCV RNA 24 weeks after end of treatment. Our hypothesis is that there is no important difference in the effect in the two groups.
This is a non-inferiority trial. The smallest difference considered to be clinically important is 10%. Thus to state "non-inferiority" the 95% confidence interval of the observed difference between the groups shall not overlap 10%. Both intention to treat and and per protocol analyses will be published. Conclusion will be conservative and based on the analysis who detect the biggest difference.
Ages Eligible for Study: | 18 Years to 70 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
HCV RNA positive Genotype 2 or 3 Treatment naive Raised ALT
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Exclusion Criteria:
Active substance abuse Poorly controlled psychiatric disease Decompensated cirrhosis HBsAg positive Anti-HIV positive Suffering from other significant concurrent medical conditions including chronic liver diseases -
Norway | |
Ullevaal University Hospital | |
Oslo, Norway, 0407 |
Principal Investigator: | Olav Dalgard, MD PhD | Ullevaal University Hospital, Oslo, Norway |
Study ID Numbers: | P03720 |
Study First Received: | March 27, 2006 |
Last Updated: | March 27, 2006 |
ClinicalTrials.gov Identifier: | NCT00308048 History of Changes |
Health Authority: | Norway: Norwegian Medicines Agency |
Interferon Pegylated interferon Pegylated interferon alfa 2b Hepatitis C Genotype 2 Genotype 3 |
Rapid virological response Short treatment 14 weeks treatment health related quality of life sick leave Injecting drug use |
Interferon-alpha Liver Diseases Immunologic Factors Ribavirin Interferons Hepatitis, Viral, Human Quality of Life Angiogenesis Inhibitors |
Antiviral Agents Hepatitis Virus Diseases Digestive System Diseases Peginterferon alfa-2b Hepatitis C Interferon Alfa-2a Interferon Alfa-2b |
Anti-Infective Agents Liver Diseases Flaviviridae Infections Immunologic Factors Antineoplastic Agents Physiological Effects of Drugs Hepatitis, Viral, Human Infection Therapeutic Uses Hepatitis C Angiogenesis Modulating Agents Growth Inhibitors Interferon-alpha |
RNA Virus Infections Growth Substances Interferons Antiviral Agents Angiogenesis Inhibitors Pharmacologic Actions Virus Diseases Hepatitis Digestive System Diseases Peginterferon alfa-2b Interferon Alfa-2a Interferon Alfa-2b |