Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsors and Collaborators: |
Universitätsklinikum Hamburg-Eppendorf German Research Foundation |
---|---|
Information provided by: | Universitätsklinikum Hamburg-Eppendorf |
ClinicalTrials.gov Identifier: | NCT00854893 |
The purpose of this study is to test the effect of transcranial direct current stimulation over the motor cortex of the language dominant hemisphere on language learning in healthy subjects and stroke patients with aphasia. We hypothesize that anodal stimulation enhances the learning of action words compared to sham and cathodal stimulation.
Condition | Intervention |
---|---|
Stroke Aphasia Aging |
Device: transcranial direct current stimulation |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Investigator, Outcomes Assessor), Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | Enhance of Language Learning With Neurostimulation (Transcranial Direct Current Stimulation) |
Estimated Enrollment: | 70 |
Study Start Date: | May 2009 |
Estimated Study Completion Date: | December 2011 |
Estimated Primary Completion Date: | May 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
anodal: Experimental
anodal stimulation: 20 min during language learning, intensity: 1 mV, anodal electrode over primary motor cortex of language-dominant hemisphere, reference electrode over contralateral supraorbital area
|
Device: transcranial direct current stimulation
1 mV for 20 min (verum conditions: anodal and cathodal)or 30 seconds (placebo condition: sham) during language learning , active electrode over primary motor cortex of language dominant hemisphere, reference electrode over contralateral supraorbital area
|
cathodal: Experimental
anodal stimulation: 20 min during language learning, intensity: 1 mV, cathodal electrode over primary motor cortex of language-dominant hemisphere, reference electrode over contralateral supraorbital area
|
Device: transcranial direct current stimulation
1 mV for 20 min (verum conditions: anodal and cathodal)or 30 seconds (placebo condition: sham) during language learning , active electrode over primary motor cortex of language dominant hemisphere, reference electrode over contralateral supraorbital area
|
sham (placebo): Experimental
sham stimulation (placebo condition): 30 seconds during language learning, intensity: 1 mV, anodal electrode over primary motor cortex of language-dominant hemisphere, reference electrode over contralateral supraorbital area
|
Device: transcranial direct current stimulation
1 mV for 20 min (verum conditions: anodal and cathodal)or 30 seconds (placebo condition: sham) during language learning , active electrode over primary motor cortex of language dominant hemisphere, reference electrode over contralateral supraorbital area
|
The motor cortex is involved at different levels of language processing. It has been demonstrated that the perception of action words activates motor representations in the language-dominant hemisphere. However, it is not known whether modulation of excitability has an effect on learning new action words. Thus, we hypothesize that transcranial direct current stimulation over the motor cortex of the language-dominant hemiphere modulates the acquisition of new action words. The results bear the potential to design new rehabilitative strategies in stroke patients with aphasia. The motor cortex might offer an access to the language network that can be used for interventional approaches such as neurostimulation.
Ages Eligible for Study: | 18 Years to 86 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Gianpiero Liuzzi, MD | +49 40 7410 ext 59278 | g.liuzzi@uke.de |
Contact: Friedhelm Hummel, MD | +49 7410 ext 53772 | f.hummel@uke.de |
Germany, HH | |
University Hospital Hamburg-Eppendorf, Department of Neurology | |
Hamburg, HH, Germany, 20246 |
Principal Investigator: | Gianpiero Liuzzi, MD | Universitätskrankenhaus Hamburg-Eppendorf |
Responsible Party: | Universitätskrankenhaus Hamburg-Eppendorf ( Dr. Gianpiero Liuzzi ) |
Study ID Numbers: | PV3128, Grant # DFG: LI 1892/1-1 |
Study First Received: | March 2, 2009 |
Last Updated: | March 2, 2009 |
ClinicalTrials.gov Identifier: | NCT00854893 History of Changes |
Health Authority: | Germany: Ethics Commission |
stroke aphasia aging language learning |
Speech Disorders Cerebral Infarction Aphasia Stroke Vascular Diseases Language Disorders Central Nervous System Diseases |
Brain Diseases Cerebrovascular Disorders Signs and Symptoms Neurologic Manifestations Neurobehavioral Manifestations Communication Disorders |
Speech Disorders Aphasia Stroke Nervous System Diseases Vascular Diseases Language Disorders Central Nervous System Diseases |
Brain Diseases Cerebrovascular Disorders Signs and Symptoms Neurologic Manifestations Cardiovascular Diseases Neurobehavioral Manifestations Communication Disorders |