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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00854464 |
Condition |
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Urothelial Carcinoma |
Study Type: | Observational |
Study Design: | Case Control, Retrospective |
Official Title: | Arsenic Methylation, Cigarette Smoking Exposure, Individual DNA Susceptibility Factors and Urothelial Carcinoma |
Estimated Enrollment: | 420 |
Study Start Date: | August 2008 |
Estimated Primary Completion Date: | July 2011 (Final data collection date for primary outcome measure) |
Urothelial carcinoma (UC) arises exclusively from the urothelium including the renal pelvis,ureter, bladder and urethra, with bladder transitional cell carcinoma (TCC) being the most common form. Arsenic is a well-established human carcinogen of the skin and lung. Recent studies have well documented that the long-term exposure to inorganic arsenic through ingestion and inhalation is associated with an increased risk of bladder cancer, especially TCC. However, the carcinogenic mechanism of arsenic-induced UC is still unclear. Recently our study found that cigarette smoking interacts with the urinary arsenic profile in modifying the UC risk. In addition, we also found that DNA damage marker 8-hydroxydeoxyguanine (8-OHdG) levels significantly higher in UC patients compared to healthy controls. The mechanism of the interaction between arsenic methylation and cigarette on UC risk is unknown. In addition, whether 8-OHdG is related to DNA repair enzymes or to inflammatory factors or not does need to explore, therefore the specific aims of this project are:
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
project recruited 420 UC patients in Taiwan University Hospital
Inclusion Criteria:
Exclusion Criteria:
-
Contact: Yeong-Shiau Pu, M.D. PhD | 886-2-23123456 ext 65249 | yspu@ntu.edu.tw |
Taiwan | |
Department of Urology/National Taiwan University Hospital | Recruiting |
Taipei, Taiwan, 10002 |
Principal Investigator: | Yeong-Shiau Pu, M.D.PhD. | National Taiwan University Hospital |
Responsible Party: | Department of Urology / National Taiwan University Hospital ( Yeong-Shiau Pu ) |
Study ID Numbers: | 200809019R |
Study First Received: | March 1, 2009 |
Last Updated: | March 2, 2009 |
ClinicalTrials.gov Identifier: | NCT00854464 History of Changes |
Health Authority: | Taiwan: Department of Health |
Arsenic Methylation Capability Arsenic Methylation Enzymes Cigarette Metabolites Cigarette Metabolic Enzymes |
DNA Repair Enzymes Inflammatory Factors Urothelial Carcinoma |
Smoking Disease Susceptibility Genetic Predisposition to Disease Carcinoma, Transitional Cell |
Transitional Cell Carcinoma Neoplasms, Glandular and Epithelial Carcinoma |
Neoplasms Neoplasms by Histologic Type Carcinoma, Transitional Cell Neoplasms, Glandular and Epithelial Carcinoma |