Inclusion Criteria:

• Histologically documented, incurable, locally advanced or metastatic solid malignancies, or NHL without leukemic phase, that has progressed despite standard of care therapy or for which there is no standard therapy of proven clinical benefit
• A biopsy-accessible lesion from which tissue can be obtained safely
• Evaluable or measurable disease per RECIST and/or the following: prostate cancer patients with non-measurable disease are eligible if they have two rising prostate-specific antigen (PSA) levels that meet the PSA Working Group criteria for progression prior to initiation of study treatment; ovarian cancer patients with non-measurable disease are eligible if they have two rising CA-125 levels greater than the ULN ≥ 2 weeks apart prior to initiation of study treatment.
• Life expectancy ≥ 12 weeks
• Adequate hematologic and organ function within 28 days before initiation of GDC-0980
• Documented willingness to use an effective means of contraception for both men and women while participating in the study

Exclusion Criteria:

• Leptomeningeal disease as the only manifestation of the current malignancy
• History of Type 1 or 2 diabetes mellitus requiring regular medication
• Grade ≥ 2 hypercholesterolemia or hypertriglyceridemia
• Any condition requiring anti-coagulants such as warfarin, heparin, or anti-thrombotics
• Malabsorption syndrome or other condition that would interfere with enteral absorption
• Known untreated malignancies of the brain or spinal cord, or treated brain metastases that are not radiographically stable for ≥ 3 months
• Active congestive heart failure or ventricular arrhythmia requiring medication
• Active infection requiring IV antibiotics
• Requirement for any daily supplemental oxygen
• Uncontrolled hypomagnesemia
• Hypercalcemia requiring continued use of bisphosphonate therapy
• Clinically significant history of liver disease, including viral or other hepatitis, current alcohol abuse, or cirrhosis
• Known HIV infection
• Significant traumatic injury within 4 weeks of Day 1
• Major surgical procedure within 4 weeks prior to initiation of GDC-0980
• Treatment with chemotherapy, hormonal therapy (except hormone replacement therapy, oral contraceptives, or GnRH agonists or antagonists for prostate cancer), immunotherapy, biologic therapy, radiation therapy (except palliative radiation to bony metastases), or herbal therapy as cancer therapy within 3 weeks prior to initiation of GDC-0980
• Palliative radiation to bony metastases within 2 weeks prior to initiation of GDC-0980
• Need for chronic corticosteroid therapy of ≥ 10 mg of prednisone per day or an equivalent dose of other anti-inflammatory corticosteroids or immunosuppressant
• Treatment with an investigational agent within 4 weeks prior to initiation of GDC-0980
• Unresolved toxicity from prior therapy except for alopecia and Grade 1 peripheral neuropathy
• Pregnancy or lactation