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Sponsored by: |
Johann Wolfgang Goethe University Hospitals |
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Information provided by: | Johann Wolfgang Goethe University Hospitals |
ClinicalTrials.gov Identifier: | NCT00365625 |
The stepwise process of leukocyte extravasation to inflamed tissues depends on the expression of a variety of cytokines and adhesion molecules. Recently much attention has focused on the Junctional Adhesion Molecules (JAM). The three members of this adhesion molecule family, namely, JAM-A, -B and -C, have been shown to govern the last step of leukocyte extravasation (transmigration) - the process of leukocytes passing between endothelial cells. In addition to transmigration, some members of this family seem to support additional steps in the leukocyte extravasation cascade. We recently showed, that antibody-mediated inhibition of JAM-C significantly reduced hapten induced skin inflammation (J Invest Dermatol;125(5):969).
Recent unpublished work from our laboratory showed, that JAM-C expression of lymphocytes can be up-regulated through specific activators. Hence, we hypothesize, that JAM-C expression is elevated in patients with psoriasis. As it is currently not know, which factors may influence the expression of JAM-C, we intend to analyse JAM-C expression on CD3+CD41- cells at several time-points during the treatment of psoriatic patients. Expression of JAM-C will then be correlated to disease activity (PASI).
Condition |
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Psoriasis Psoriasis Vulgaris |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Official Title: | Patient Orientated Basic Science Investigation: Determination of Lymphocyte JAM-C Expression in Patients With Psoriasis Vulgaris |
Estimated Enrollment: | 30 |
Study Start Date: | July 2005 |
Estimated Study Completion Date: | December 2007 |
The stepwise process of leukocyte extravasation to inflamed tissues depends on the expression of a variety of cytokines and adhesion molecules. Recently much attention has focused on the Junctional Adhesion Molecules (JAM). The three members of this adhesion molecule family, namely, JAM-A, -B and -C, have been shown to govern the last step of leukocyte extravasation (transmigration) - the process of leukocytes passing between endothelial cells. In addition to transmigration, some members of this family seem to support additional steps in the leukocyte extravasation cascade. We recently showed, that antibody-mediated inhibition of JAM-C significantly reduced hapten induced skin inflammation (J Invest Dermatol;125(5):969).
Recent unpublished work from our laboratory showed, that JAM-C expression of lymphocytes can be up-regulated through specific activators. Hence, we hypothesize, that JAM-C expression is elevated in patients with psoriasis. As it is currently not know, which factors may influence the expression of JAM-C, we intend to analyse JAM-C expression on CD3+CD41- cells at several time-points during the treatment of psoriatic patients. Expression of JAM-C will then be correlated to disease activity (PASI).
Detailed in- and exclusion criteria are outlined below.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Ralf J Ludwig, MD | 0049-69-6301- ext 6162 | r.ludwig@em.uni-frankfurt.de |
Contact: Wolf-Henning Boehncke, Professor | 0049-69-6301- ext 5743 | boehncke@em.uni-frankfurt.de |
Germany, Hessen | |
Department of Dermatology - Clinic of the Johann Wolfgang Goethe University | Recruiting |
Frankfurt am Main, Hessen, Germany, 60590 | |
Contact: Ralf J Ludwig, MD 0049-69-6301- ext 6162 r.ludwig@em.uni-frankfurt.de | |
Contact: Wolf-Henning Boehncke, Professor 0049-69-6301- ext 5743 boehncke@em.uni-frankfurt.de |
Principal Investigator: | Ralf J Ludwig, MD | Department of Dermatology - Clinic of the Johann Wolfgang Goethe University |
Study Chair: | Roland Kaufmann, Professor | Department of Dermatology - Clinic of the Johann Wolfgang Goethe University |
Study Chair: | Wolf-Henning Boehncke, Professor | Department of Dermatology - Clinic of the Johann Wolfgang Goethe University |
Study ID Numbers: | 244/06 |
Study First Received: | August 16, 2006 |
Last Updated: | April 3, 2007 |
ClinicalTrials.gov Identifier: | NCT00365625 History of Changes |
Health Authority: | Germany: Ethics Commission |
Psoriasis JAM3 protein, human Cell Adhesion Molecules |
Skin Inflammation Lymphocytes |
Skin Diseases Psoriasis Adhesions Skin Diseases, Papulosquamous Inflammation |
Skin Diseases Psoriasis Skin Diseases, Papulosquamous |