Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsors and Collaborators: |
Weill Medical College of Cornell University National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) |
---|---|
Information provided by: | Weill Medical College of Cornell University |
ClinicalTrials.gov Identifier: | NCT00195052 |
Epilepsy is a disease affecting 1-2% of the population. Currently, the only known cure for epilepsy is surgery, which is much more effective at eliminating seizures arising from the medial temporal lobe compared with the neocortex. The problem with neocortical epilepsy is that the population of neurons underlying each epileptiform discharge varies over time. In addition, the spatial relationship between interictal events and the ictal onset zones, which are critical in defining the region of epileptogenesis, is not well understood and essential to the surgical treatment of epilepsy.
Electrophysiological recording methods, although currently the "gold standard" in mapping epilepsy, are inadequate to address these questions based on restrictions due to volume conduction or sampling limitations. Optical recording techniques can overcome many of these limitations by sampling large areas of cortex simultaneously to provide information about blood flow, metabolism and extracellular fluid shifts that are intimately related to excitatory and inhibitory neuronal activity. In fact, optical recordings may actually be more sensitive to certain aspects of epileptic activity than electrophysiologic recordings. The goal will be to translate these findings into the operating room and map human neocortical epilepsy with the same optical techniques. Outcome following surgical resections to treat neocortical epilepsy will be correlated with the optical maps to determine the utility of intrinsic signal imaging in guiding brain surgery. These experiments will set the groundwork for implementing optical recordings in general clinical practice as a novel technique for mapping and predicting human seizures.
Condition |
---|
Epilepsy |
Study Type: | Observational |
Study Design: | Case-Only |
Official Title: | Intraoperative Optical Imaging Mapping of Neocortical Epilepsy in Human |
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
The patient, who is going to undergo a neurosurigcal procedure which will require intraoperative brain mapping to determine the brain organization, is the potential study subject.
Inclusion Criteria:
Exclusion Criteria:
-
Contact: Theodore H Schwartz, MD | 212-746-5620 |
United States, New York | |
Weill Cornell Medical College/New York Presbyterian Hospital | Recruiting |
New York, New York, United States, 10021 |
Principal Investigator: | Theodore H Schwartz, MD | Weill Cornell Medical College/New York Presbyterian Hospital |
Responsible Party: | The Newyork-Presbyterian hospital-Weill Cornell Medical College of Cornell University ( Theodore H. Schwartz ) |
Study ID Numbers: | 0102004808 |
Study First Received: | September 14, 2005 |
Last Updated: | April 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00195052 History of Changes |
Health Authority: | United States: Institutional Review Board |
Epilepsy Seizures Central Nervous System Diseases Brain Diseases |
Epilepsy Nervous System Diseases Central Nervous System Diseases Brain Diseases |