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Study Topics
Glossary
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Sponsors and Collaborators: |
Uniformed Services University of the Health Sciences Infectious Diseases Clinical Research Program National Institute of Allergy and Infectious Diseases (NIAID) |
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Information provided by: | Uniformed Services University of the Health Sciences |
ClinicalTrials.gov Identifier: | NCT00859677 |
The purpose of this study is to investigate the role of Th17 cells in the pathogenesis of MRSA infections.
Condition |
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HIV Infections Staphylococcal Infections |
Study Type: | Observational |
Study Design: | Cohort, Cross-Sectional |
Official Title: | Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection |
Skin biopsy will be obtained.
Estimated Enrollment: | 60 |
Study Start Date: | March 2009 |
Estimated Study Completion Date: | October 2010 |
Estimated Primary Completion Date: | March 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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HIV-positive and MRSA negative
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HIV-positive and MRSA infected (skin/soft tissue)
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HIV-positive and MRSA colonized
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HIV-negative and MRSA negative
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5
HIV-negative and MRSA infected (skin/soft tissue)
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6
HIV-negative and MRSA colonized
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
HIV-positive and negative patients with a recent screen for MRSA colonization or a history of MRSA infection will be asked to participate.
Participants will be recruited by providers within the infectious disease clinics at the sites. In addtion, MRSA isolates will be monitored at the central laboratory and providers of patients with MRSA will be notified and asked to notify their patients of the opportunity to participate in this study.
All participant inclusion criteria:
-AND-
HIV-positive and MRSA-negative Group:
HIV-positive and MRSA-Colonization Group:
HIV-positive and MRSA Infection Group:
HIV Negative groups:
Exclusion Criteria:
Contact: Edith Lederman, MD | 619-532-7475 | edith.lederman@med.navy.mil |
Contact: Nancy Crum-Cianflone, MD, MPH | 619-532-7475 | nancy.crum@med.navy.mil |
United States, California | |
Naval Medical Center San Diego | Recruiting |
San Diego, California, United States, 92134 | |
Contact: Alona Mask, MA 619-532-9812 alona.mask@med.navy.mil | |
Sub-Investigator: Nancy Crum-Cianflone, MD, MPH | |
United States, District of Columbia | |
Walter Reed Army Medical Center | Not yet recruiting |
Washington, District of Columbia, United States, 20307 | |
Contact: David Wallace 202-782-8754 david.wallace@amedd.army.mil | |
Principal Investigator: Glenn Wortmann, MD |
Principal Investigator: | Edith Lederman, MD | NMCSD |
Responsible Party: | Infectious Diseases Clinical Research Program ( Edith Lederman, MD ) |
Study ID Numbers: | IDCRP -023 |
Study First Received: | March 10, 2009 |
Last Updated: | March 10, 2009 |
ClinicalTrials.gov Identifier: | NCT00859677 History of Changes |
Health Authority: | United States: Institutional Review Board |
HIV Methicillin-resistant Staphylococcus aureus (MRSA) HIV and Staphylococcus aureus infection |
Bacterial Infections Sexually Transmitted Diseases, Viral Disease Susceptibility Acquired Immunodeficiency Syndrome Immunologic Deficiency Syndromes Virus Diseases Anti-Bacterial Agents |
Staphylococcal Infections Gram-Positive Bacterial Infections Methicillin HIV Infections Sexually Transmitted Diseases Genetic Predisposition to Disease Retroviridae Infections |
Bacterial Infections Communicable Diseases Anti-Infective Agents Sexually Transmitted Diseases, Viral Disease Attributes Slow Virus Diseases Infection Anti-Bacterial Agents Gram-Positive Bacterial Infections Pathologic Processes Methicillin Therapeutic Uses Genetic Predisposition to Disease |
Retroviridae Infections RNA Virus Infections Disease Susceptibility Immune System Diseases Acquired Immunodeficiency Syndrome Immunologic Deficiency Syndromes Pharmacologic Actions Virus Diseases Staphylococcal Infections HIV Infections Sexually Transmitted Diseases Lentivirus Infections |