Effect of Sildenafil on Endothelial Function - Full Text View

Sponsors and Collaborators:	Rambam Health Care Campus Pfizer
Information provided by:	Rambam Health Care Campus
ClinicalTrials.gov Identifier:	NCT00297544

Purpose

We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Condition	Intervention
Impotence	Drug: Viagra

MedlinePlus related topics: Erectile Dysfunction

Drug Information available for: Sildenafil Sildenafil citrate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Educational/Counseling/Training, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Official Title:	Effect of Sildenafil on Endothelial Function

Further study details as provided by Rambam Health Care Campus:

Primary Outcome Measures:

Improvement of endothelial function following Viagra treatment, according to platismographia.

Estimated Enrollment:	60
Study Start Date:	October 2005

Detailed Description:

We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors

Eligibility

Ages Eligible for Study:	40 Years to 70 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

age 40-70
impotence
with and without hypertension, Hypercholesteremia or DM

Exclusion Criteria:

CHF: NYHA > II
Stable angina: CCS > II
Nitrate treatment

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00297544

Contacts

Contact: Giris Jacob, Prof., MD, DSc	972-4-854-2467	g_jacob@rambam.health.gov.il
Contact: Yuram Vardi, Prof. , MD	972-4-854-2819	y_vardi@rambam.health.gov.il

Locations

Israel
Rambam Medical Center, Recanati Autonomic Dysfunction CTR	Recruiting
Haifa, Israel, 31096
Contact: Giris Jacob, MD, DSc 972-4-854-2594 g_Jacob@rambam.health.gov.il
Principal Investigator: Yuram Vardi, MD

Sponsors and Collaborators

Rambam Health Care Campus

Pfizer

Investigators

Principal Investigator:

Giris Jacob, Prof, MD, DSc

Rambam Health Care Campus

More Information

Publications:

Dayan L, Greunwald I, Vardi Y, Jacob G. A new clinical method for the assessment of penile endothelial function using the flow mediated dilation with plethysmography technique. J Urol. 2005 Apr;173(4):1268-72.

Study ID Numbers:	1777-CTIL
Study First Received:	February 27, 2006
Last Updated:	February 27, 2006
ClinicalTrials.gov Identifier:	NCT00297544 History of Changes
Health Authority:	Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Rambam Health Care Campus:

impotence
endothelial function
autonomic nervous system

Study placed in the following topic categories:

Sexual Dysfunctions, Psychological
Vasodilator Agents
Phosphodiesterase Inhibitors
Sexual Dysfunction, Physiological
Mental Disorders

Sildenafil
Cardiovascular Agents
Genital Diseases, Male
Erectile Dysfunction

Additional relevant MeSH terms:

Sexual Dysfunctions, Psychological
Vasodilator Agents
Molecular Mechanisms of Pharmacological Action
Sildenafil
Enzyme Inhibitors
Cardiovascular Agents
Genital Diseases, Male

Sexual and Gender Disorders
Pharmacologic Actions
Sexual Dysfunction, Physiological
Phosphodiesterase Inhibitors
Mental Disorders
Therapeutic Uses
Erectile Dysfunction

ClinicalTrials.gov processed this record on May 06, 2009