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| Sponsors and Collaborators: |
University of Schleswig-Holstein Abbott |
|---|---|
| Information provided by: | University of Schleswig-Holstein |
| ClinicalTrials.gov Identifier: | NCT00569816 |
Purpose
Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.
| Condition | Intervention | Phase |
|---|---|---|
|
Myocardial Injury |
Drug: Sevoflurane |
Phase IV |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Single Blind (Subject), Active Control, Parallel Assignment, Efficacy Study |
| Official Title: | A Comparison Between Continuous and Repetitive Sevoflurane Administration for Preconditioning During Coronary Artery Bypass Surgery |
| Enrollment: | 50 |
| Study Start Date: | January 2005 |
| Study Completion Date: | May 2007 |
| Arms | Assigned Interventions |
|---|---|
|
Group 1: Active Comparator
Propofol as the primary anesthetic
|
Drug: Sevoflurane
1 MAC Sevoflurane will be given either continuously after induction of anesthesia until initiation of cardiopulmonary bypass or will be repetitively washed in and out twice before initiation of cardiopulmonary bypass.
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Group 2: Experimental
Sevoflurane administered continuously after induction of anesthesia until initiation of cardiopulmonary bypass.
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Drug: Sevoflurane
1 MAC Sevoflurane will be given either continuously after induction of anesthesia until initiation of cardiopulmonary bypass or will be repetitively washed in and out twice before initiation of cardiopulmonary bypass.
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|
Group 3: Experimental
Sevoflurane administered repetitive up to 1 MAC from induction of anesthesia until initiation of cardiopulmonary bypass. Wash in and wash out performed twice.
|
Drug: Sevoflurane
1 MAC Sevoflurane will be given either continuously after induction of anesthesia until initiation of cardiopulmonary bypass or will be repetitively washed in and out twice before initiation of cardiopulmonary bypass.
|
Eligibility| Ages Eligible for Study: | 18 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Germany | |
| University Hospital Schleswig-Holstein, Campus Kiel | |
| Kiel, Germany, 24105 | |
| Principal Investigator: | Jens Scholz, MD | University Hospital Schleswig-Holstein, Campus Kiel, Department of Anaesthesiology and Intensive Care Medicine |
More Information
| Responsible Party: | University Hospital Schleswig-Holstein, Campus Kiel, Department of Anaesthesiology and Intensive Care Medicine ( Prof. Dr. Jens Scholz ) |
| Study ID Numbers: | UKSHCK-Anae07/06, ACA-GmbH-03-7 |
| Study First Received: | December 6, 2007 |
| Last Updated: | December 6, 2007 |
| ClinicalTrials.gov Identifier: | NCT00569816 History of Changes |
| Health Authority: | Germany: Ethics Commission |
|
myocardial protection pharmacological preconditioning volatile anesthetics myocardial injury following CABG surgery |
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Anesthetics, Inhalation Anesthetics, General Central Nervous System Depressants |
Anesthetics Platelet Aggregation Inhibitors Sevoflurane |
|
Anesthetics, Inhalation Anesthetics, General Therapeutic Uses Physiological Effects of Drugs Hematologic Agents Central Nervous System Depressants |
Anesthetics Platelet Aggregation Inhibitors Central Nervous System Agents Pharmacologic Actions Sevoflurane |
