Inclusion Criteria:Both genders and individuals from all ethnic groups will be eligible.

1. Patients greater than or equal to 50 years of age and less than or equal to 75 years of age.
2. Patients with de novo AML based on FAB and WHO criteria.
3. Patients with intermediate or unfavorable cytogenetic abnormalities based on SWOG Cytogenetic Criteria.

4. Patients achieving a 1st morphologic CR, or CRp (a complete remission but with low platelets) following one or two courses of induction therapy.

   (See definition of CR on page 6.) CR must be documented no more than 8 weeks prior to the date of enrollment.

5. Patients fit for nonmyeloablative transplantation or best treatment.
6. Patients able to understand and willing to sign a written informed consent document.
 Exclusion Criteria:1. Patients with AML with favorable cytogenetic features based on SWOG Cytogenetic Criteria.

2. Patients not in a Complete Remission at time of enrollment.

3. Patients with treatment-related or MDS-related AML.

4. CR documented >8 weeks prior to date of enrollment.

5. Patients with active CNS disease as identified by positive CSF cytospin at time of enrollment.

6. Patients with prior or concurrent malignancies except localized non-melanoma skin malignancies or treated cervical carcinoma in situ. Cancer treated with curative intent <5 years previously will not be allowed. Cancer treated with curative intent >5 years previously will be allowed. Patients with low grade lymphomas are eligible as long as they have not and do not require active treatment for control of their disease.

7. Patients planned for allogeneic transplant using a full-dose conditioning, irrespective of knowledge of donor status.

8. Patients whose life expectancy is severely limited (<1 year) by diseases other than malignancy.

9. Karnofsky Performance Score <60.

10. Patients who are pregnant or breastfeeding.

11. Patients who are HIV seropositive.

12. Patients who have an uncontrolled infection (presumed or documented) with progression after appropriate therapy for greater than one month.

13. Patients with symptomatic coronary artery disease, uncontrolled congestive heart failure. Left Ventricular Ejection Fraction is not required to be measured, however if it is measured, patient is excluded if ejection fraction is <30%.

14. Patients requiring supplementary continuous oxygen. DLCO is not required to be measured, however if it is measured, patient is excluded if DLCO <35%.

15. Patients with clinical or laboratory evidence of liver disease will be evaluated for the cause of liver disease, its clinical severity in terms of liver function and histology, and for the degree of portal hypertension. Patients with any of the following liver function abnormalities will be excluded:

1. Fulminant liver failure.
2. Cirrhosis with evidence of portal hypertension or bridging fibrosis.
3. Alcoholic hepatitis.
4. Esophageal varices.
5. A history of bleeding esophageal varices.
6. Hepatic encephalopathy.
7. Uncorrectable hepatic synthetic dysfunction evidenced by prolongation of the prothrombin time.
8. Ascites related to portal hypertension.
9. Chronic viral hepatitis with total serum bilirubin >3 mg/dL.
10. Symptomatic biliary disease.