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Sponsors and Collaborators: |
Minneapolis Veterans Affairs Medical Center Minnesota Veterans Research Institute |
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Information provided by: | Minneapolis Veterans Affairs Medical Center |
ClinicalTrials.gov Identifier: | NCT00568087 |
The present study is designed to find out if N-acetylcysteine works in reducing alcohol drinking and craving.
Condition | Intervention | Phase |
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Alcoholism |
Drug: N-acetylcysteine Drug: Placebo |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | N-Acetylcysteine in Alcohol Dependence |
Estimated Enrollment: | 60 |
Study Start Date: | December 2007 |
Estimated Study Completion Date: | June 2009 |
Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Active Comparator |
Drug: N-acetylcysteine
Oral N-acetylcysteine daily for 8 weeks
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2: Placebo Comparator |
Drug: Placebo
Placebo
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The 2 groups (placebo and N-acetylcysteine) will be compared in a double-blind, placebo-controlled trial. The total study duration is 9 weeks which includes a 1-week screening period and an 8-week randomized study drug treatment period.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Gihyun Yoon, MD | 612-467-3996 | gihyun.yoon@va.gov |
United States, Minnesota | |
Minneapolis VA Medical Center | Recruiting |
Minneapolis, Minnesota, United States, 55417 |
Principal Investigator: | Gihyun Yoon, MD | Minneapolis Veterans Affairs Medical Center |
Responsible Party: | Minneapolis VAMC ( Gihyun Yoon, MD ) |
Study ID Numbers: | Protocol #3852-B |
Study First Received: | December 4, 2007 |
Last Updated: | January 14, 2009 |
ClinicalTrials.gov Identifier: | NCT00568087 History of Changes |
Health Authority: | United States: Federal Government |
N-acetylcysteine Alcoholism Treatment |
Antioxidants Mental Disorders Expectorants Alcoholism Substance-Related Disorders Acetylcysteine |
Disorders of Environmental Origin Alcohol-Related Disorders Antiviral Agents N-monoacetylcystine Ethanol |
Anti-Infective Agents Respiratory System Agents Antioxidants Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Disorders of Environmental Origin Protective Agents Antiviral Agents Pharmacologic Actions Mental Disorders |
Expectorants Therapeutic Uses Alcoholism Free Radical Scavengers Substance-Related Disorders Acetylcysteine Alcohol-Related Disorders N-monoacetylcystine Antidotes |