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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00155753 |
The purpose of this study is to evaluate the possible candidate gene of pathological myopia
Condition |
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Pathological Myopia |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Case Control, Retrospective/Prospective Study |
Official Title: | National Taiwan University Hospital |
Estimated Enrollment: | 600 |
Study Start Date: | August 2002 |
Estimated Study Completion Date: | July 2006 |
High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a genetic component to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. The ocular components (axial length, anterior chamber depth, and corneal curvature) and refractive errors of MZ twins are more closely aligned than are those of DZ twins.
Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Yung-Feng Shih, MD | 886-2-23123456 ext 5184 | yfshih@ha.mc.ntu.edu.tw |
Taiwan | |
National Taiwan University Hospital | Recruiting |
Taipei, Taiwan, 100 | |
Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184 yfshih@ha.mc.ntu.edu.tw |
Principal Investigator: | Yung-Feng Shih, MD | National Taiwan University Hospiyal |
Study ID Numbers: | 9100205245 |
Study First Received: | September 9, 2005 |
Last Updated: | September 9, 2005 |
ClinicalTrials.gov Identifier: | NCT00155753 History of Changes |
Health Authority: | Taiwan: Department of Health |
pathological myopia, genomic |
Eye Diseases Myopia Myopia, Degenerative Refractive Errors |
Eye Diseases Myopia Myopia, Degenerative Refractive Errors |