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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00154700 |
The primary objective of this study is to find out the response rate of twice weekly paclitaxel and cisplatin and weekly HDFL in recurrent or metastatic esophageal carcinoma patients who need palliative Chemotherapy.
Condition | Intervention | Phase |
---|---|---|
Esophageal Cancer |
Drug: Paclitaxel,Cisplatin,5-Fu,Folic Acid |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study |
Official Title: | A Phase II Study of Twice Weekly Paclitaxel, Cisplatin and Weekly 24-Hour Infusion of High-Dose 5-Fluorouracil and Folinic Acid in the Treatment of Recurrent or Metastatic Esophageal Cancer |
Estimated Enrollment: | 40 |
Study Start Date: | January 2001 |
Estimated Study Completion Date: | July 2005 |
The primary objective of this study is to find out the response rate of twice weekly paclitaxel and cisplatin and weekly HDFL in recurrent or metastatic esophageal carcinoma patients who need palliative Chemotherapy. The secondary objectives include overall survival, progression-free survival, and toxicity.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Taiwan | |
Department of Oncology, National Taiwan University Hospital | |
Taipei, Taiwan, 100 |
Study Chair: | Ann-Lii Cheng, M.D., Ph.D. | Department of Oncology, National Taiwan University hospital |
Study Chair: | Ann-Lii Cheng, M.D.,Ph.D | Department of Oncology, National Taiwan University Hospital |
Study ID Numbers: | 159I9 |
Study First Received: | September 8, 2005 |
Last Updated: | December 19, 2005 |
ClinicalTrials.gov Identifier: | NCT00154700 History of Changes |
Health Authority: | Taiwan: Department of Health |
Combination,Chemotherapy,Esophageal Cancer |
Digestive System Neoplasms Gastrointestinal Diseases Esophageal Neoplasms Leucovorin Esophageal Cancer Antimitotic Agents Recurrence Folic Acid Digestive System Diseases Radiation-Sensitizing Agents |
Cisplatin Esophageal Disorder Paclitaxel Fluorouracil Head and Neck Neoplasms Tubulin Modulators Gastrointestinal Neoplasms Esophageal Diseases Antineoplastic Agents, Phytogenic |
Digestive System Neoplasms Molecular Mechanisms of Pharmacological Action Gastrointestinal Diseases Antineoplastic Agents Esophageal Neoplasms Mitosis Modulators Physiological Effects of Drugs Antimitotic Agents Pharmacologic Actions Neoplasms Digestive System Diseases |
Neoplasms by Site Radiation-Sensitizing Agents Cisplatin Paclitaxel Head and Neck Neoplasms Therapeutic Uses Tubulin Modulators Gastrointestinal Neoplasms Esophageal Diseases Antineoplastic Agents, Phytogenic |