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Sponsored by: |
Holstebro Hospital |
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Information provided by: | Holstebro Hospital |
ClinicalTrials.gov Identifier: | NCT00298753 |
Patients treated with the antiepileptic drug Oxcarbazepine often develop syndrome of inappropriate secretion of antidiuretic hormone(SIADH)We want to test the hypothesis, that these patients have a higher reabsorption of water during the Aquaporine2 water channels,a higher concentration of Vasopressine (AVP), and a lower clearance of water.This situation will tend to normalize, when the patients are treated with fluid restriction
Condition | Intervention | Phase |
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Syndrome of Inappropriate ADH-Secretion |
Procedure: fluid restriction for 14 days (15ml fluid per kg weight) |
Phase IV |
Study Type: | Interventional |
Study Design: | Non-Randomized, Open Label, Placebo Control, Parallel Assignment |
Official Title: | Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-Secretion Caused by Treatment With Antiepileptic Medicine |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Age more than 18 years, both men and women, patients with epilepsia treated with Oxcarbazepine, and a Sodium content in plasma lower than 130 mmol/liter
Exclusion Criteria:
severe diseases in the heart, lungs or liver;diabetes mellitus, other not-well treated diseases in endocrine organs, cancer; unwillingness to participate
Denmark, Jutland | |
Department of Medicine, Holstebro Hospital | |
Holstebro, Jutland, Denmark, 7500 |
Study Chair: | Erling B Pedersen, Professor | Holstebro Hospital, Denmark |
Study ID Numbers: | MED.RES.HOS.2005.04/IMT |
Study First Received: | March 1, 2006 |
Last Updated: | July 11, 2007 |
ClinicalTrials.gov Identifier: | NCT00298753 History of Changes |
Health Authority: | Denmark: Ethics Committee |
Hypothalamic Diseases Inappropriate ADH Syndrome Metabolic Diseases Syndrome of Inappropriate Antidiuretic Hormone Pituitary Diseases Endocrine System Diseases |
Central Nervous System Diseases Water-Electrolyte Imbalance Endocrinopathy Brain Diseases Metabolic Disorder Anticonvulsants |
Inappropriate ADH Syndrome Hypothalamic Diseases Metabolic Diseases Disease Pituitary Diseases Nervous System Diseases Central Nervous System Diseases Endocrine System Diseases |
Brain Diseases Pharmacologic Actions Pathologic Processes Therapeutic Uses Syndrome Water-Electrolyte Imbalance Central Nervous System Agents Anticonvulsants |