ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly - Full Text View

Sponsors and Collaborators:	National Institute on Aging (NIA) National Institute of Nursing Research (NINR)
Information provided by:	National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:	NCT00298558

Purpose

The purpose of the ACTIVE study was to test if cognitive training interventions could maintain functional independence in elders by improving basic mental abilities, with follow-up assessments through five years.

Condition	Intervention	Phase
Aging Healthy	Behavioral: ACTIVE	Phase II Phase III

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Prevention, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study
Official Title:	Trial of a Cognitive Intervention for Older Adults

Further study details as provided by National Institute on Aging (NIA):

Primary Outcome Measures:

Changes in cognitive abilities and daily function

Secondary Outcome Measures:

Changes in health-related quality of life (HRQol), driving function, health service use

Estimated Enrollment:	2832
Study Start Date:	March 1998
Estimated Study Completion Date:	December 2004

Show Detailed Description

Eligibility

Ages Eligible for Study:	65 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Age 65 or older
MMSE score 23 or greater
Vision scored greater than 20/50
Minimal dependence in hygiene, bathing, and dressing

Exclusion Criteria:

Significant decline in cognitive skills, physical abilities, or functional independence
Inability to complete study activities as evidenced by MMSE and vision scores lower than Inclusion Criteria requirement
Diagnosis of Alzheimer's disease
Stroke in previous 12 months
Cancer with limited life expectance
Current chemotherapy or radiation treatment
Communication problems
Planned move from study area
Scheduling conflicts that would preclude participation in study activities
Prior involvement in similar cognitive training studies

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00298558

Locations

United States, Alabama
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
United States, Indiana
Indiana University
Indianapolis, Indiana, United States, 46202
United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21205
Johns Hopkins University
Cumberland, Maryland, United States, 21205
United States, Massachusetts
Hebrew Rehabilitation Center for the Aged
Boston, Massachusetts, United States, 02131
United States, Michigan
Wayne State University
Detroit, Michigan, United States, 48202
United States, Pennsylvania
Pennsylvania State University
University Park, Pennsylvania, United States, 16802

Sponsors and Collaborators

National Institute on Aging (NIA)

National Institute of Nursing Research (NINR)

Investigators

Principal Investigator:	Karlene Ball, PhD	University of Alabama at Birmingham
Principal Investigator:	Frederick Unverzagt, PhD	Indiana University
Principal Investigator:	George Rebok, PhD	Johns Hopkins University
Principal Investigator:	John Morris, PhD	Hebrew Senior Life
Principal Investigator:	Sharon L. Tennstedt, PhD	New England Research Institutes
Principal Investigator:	Michael Marsiske, PhD	Wayne State University
Principal Investigator:	Sherry Willis, PhD	Penn State University

More Information

Publications:

Ball K, Berch DB, Helmers KF, Jobe JB, Leveck MD, Marsiske M, Morris JN, Rebok GW, Smith DM, Tennstedt SL, Unverzagt FW, Willis SL; Advanced Cognitive Training for Independent and Vital Elderly Study Group. Effects of cognitive training interventions with older adults: a randomized controlled trial. JAMA. 2002 Nov 13;288(18):2271-81.

Jobe JB, Smith DM, Ball K, Tennstedt SL, Marsiske M, Willis SL, Rebok GW, Morris JN, Helmers KF, Leveck MD, Kleinman K. ACTIVE: a cognitive intervention trial to promote independence in older adults. Control Clin Trials. 2001 Aug;22(4):453-79.

Jones RN, Rosenberg AL, Morris JN, Allaire JC, McCoy KJ, Marsiske M, Kleinman KP, Rebok GW, Malloy PF. A growth curve model of learning acquisition among cognitively normal older adults. Exp Aging Res. 2005 Jul-Sep;31(3):291-312.

Kuo HK, Jones RN, Milberg WP, Tennstedt S, Talbot L, Morris JN, Lipsitz LA. Cognitive function in normal-weight, overweight, and obese older adults: an analysis of the advanced cognitive training for independent and vital elderly cohort. J Am Geriatr Soc. 2006 Jan;54(1):97-103.

Diehl M, Marsiske M, Horgas A, Rosenberg A, Saczynski J, and Willis S. The revised observed tasks of daily living: A performance-based assessment of everyday problem solving. Journal of Applied Gerontology 2005 24(3): 211-230.

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Willis SL, Tennstedt SL, Marsiske M, Ball K, Elias J, Koepke KM, Morris JN, Rebok GW, Unverzagt FW, Stoddard AM, Wright E; ACTIVE Study Group. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA. 2006 Dec 20;296(23):2805-14.

Study ID Numbers:	IA0091, U01NR04507, U01NR04508, U01AG014260, U01AG014282, U01AG014263, U01AG014289, U01AG014276
Study First Received:	February 28, 2006
Last Updated:	February 28, 2006
ClinicalTrials.gov Identifier:	NCT00298558 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institute on Aging (NIA):

cognition disorder
cognitive behavior therapy
functional ability

Study placed in the following topic categories:

Healthy
Cognition Disorders

ClinicalTrials.gov processed this record on May 06, 2009