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Sponsored by: |
Hadassah Medical Organization |
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Information provided by: | Hadassah Medical Organization |
ClinicalTrials.gov Identifier: | NCT00305513 |
Unilateral spatial neglect (USN) is believed to be a disorder of attention, characterized by impairment in the ability to perceive or respond to stimuli presented to the contralesional space, and which is not attributable to significant sensory or motor deficits. USN has serious consequences for rehabilitation and long term disabilities. Efforts have been made to clarify both the theoretical basis of this phenomenon and the rehabilitation methods that will be best in improving function. The purpose of this study is to try and contribute to both efforts by examining treatment effectiveness of two methods; one targeting general arousal (phasic alerting), and the other targeting increasing awareness to left side stimuli and habit changes. Functional neuroimaging methods (PET [positron emission tomography] and fMRI [functional magnetic resonance imaging]) have been applied to understand the functional anatomy of the brain during mental processes. Only a few attempts have been made to use functional neuroimaging in patients with neurological deficits such as USN, usually speculations are made based on findings with healthy participants to explain this disorder. This study's aim is to examine the functional reorganization of the attentional network in the brain of USN patients while performing visual tasks, by means of functional neuroimaging techniques, in light of specific rehabilitation techniques. Patients will be examined before and after 3 weeks of rehabilitation both using standardized neurobehavioral tests and PET imaging procedures.
Condition | Intervention | Phase |
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Cerebrovascular Accident Perceptual Disorders |
Procedure: The phasic alerting treatment |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Effectiveness of Rehabilitation (Phasic Alerting and Visual Spatial Scanning Training) on the Recovery of Patients Post Right Stroke With Unilateral Spatial Neglect: Using Functional Imaging PET and Standardized Neurobehavioral and Functional Tests |
Estimated Enrollment: | 6 |
Procedure:
Inclusion criteria:
Participants:
Ages Eligible for Study: | 25 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Contact: Zeev Meiner, MD | 00 972 2 5844582 | MEINER@hadassah.org.il |
Israel | |
Hadassah Medical Organization | |
Jerusalem, Israel, 91120 |
Principal Investigator: | Zeev Meiner, MD | Hadassah Medical Organization |
Study ID Numbers: | 10-17.02.06-HMO-CTIL |
Study First Received: | March 21, 2006 |
Last Updated: | September 4, 2007 |
ClinicalTrials.gov Identifier: | NCT00305513 History of Changes |
Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
right hemispheric CVA neglect phasic alert treatment PET scan patients post right hemispheric CVA (stroke) |
Cerebral Infarction Stroke Vascular Diseases Central Nervous System Diseases Ischemia Brain Diseases Cerebrovascular Disorders |
Signs and Symptoms Neurologic Manifestations Brain Ischemia Brain Infarction Infarction Neurobehavioral Manifestations Perceptual Disorders |
Cerebral Infarction Stroke Nervous System Diseases Vascular Diseases Central Nervous System Diseases Brain Diseases Cerebrovascular Disorders |
Signs and Symptoms Neurologic Manifestations Brain Ischemia Cardiovascular Diseases Brain Infarction Neurobehavioral Manifestations Perceptual Disorders |