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Pulmonary Infections Masquerading as Community-Acquired Pneumonia
This study is currently recruiting participants.
Verified by VA Medical Center, Houston, July 2005
First Received: March 16, 2006   No Changes Posted
Sponsors and Collaborators: VA Medical Center, Houston
Baylor College of Medicine
Information provided by: VA Medical Center, Houston
ClinicalTrials.gov Identifier: NCT00304395
  Purpose

The purpose of this research is to identify cases from patients who have been referred for consultation to the Infectious Disease Section at the VAMC, Houston, and to compare them with other cases of CAP in order to determine wheteher there are features that might enable non-CAP cases to be distinguished from CAP.


Condition Phase
Pneumonia
Phase IV

MedlinePlus related topics: Pneumonia
U.S. FDA Resources
Study Type: Observational
Study Design: Natural History, Cross-Sectional, Defined Population, Retrospective Study
Official Title: Pulmonary Infections Masquerading as Community-Acquired Pneumonia

Further study details as provided by VA Medical Center, Houston:

Estimated Enrollment: 60
Detailed Description:

Guidelines to treat community acquired pneumonia (CAP) have been developed and widely promulgated by important professional societies in the past 10 years. The impetus to do so came from the observation that practicing physicians were using a wide array of approaches to this common infection, many of which were substandard.

The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have been leaders in this field, publishing recommendations separately between 1993 and 2003. The PI served on the IDSA committee and coauthored the publication in 2000 and the update in 2003. In 2004, a decision was made by the two professional societies to merge the committees and make a single joint set of recommendations; the PI is a member of that joint committee and a new document is being prepared for publication.

The PI has observed a tendency to apply these guidelines to cases that might masquerade as CAP but are actually attributable to other conditions, such as lung cancer, tuberculosis and histoplasmosis. Further, the recommendations do not adequately cover pneumonia due to Staphylococcus aureus.

The purpose of the research is to identify cases from the consult records of the Infectious Disease Section at the VAMC, Houston, and to compare them with other cases of CAP in order to determine whether there are features that might enable non-CAP cases to be distinguished from CAP.

  Eligibility

Ages Eligible for Study:   18 Years to 64 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • subjects who were seen in calendar year 2004 because they were thought to have CAP, but who, upon further evaluation, plainly did not, and consultation was sought.
  • case control is diagnosis of CAP with verification by all or nearly all of the following features: presence of cough, increased sputum, fever, leukocytosis and a distinct new pulmonary infiltrate.

Exclusion Criteria:

  • among the case controls, if the diagnosis of CAP was made despite the absence of the cardinal features of CAP, as cited above, we will not include the case.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00304395

Contacts
Contact: Daniel M Musher, M.D. 713-794-7384 dmusher@bcm.tmc.edu

Locations
United States, Texas
Michael E. DeBakey Veterans Affairs Medical Center Recruiting
Houston, Texas, United States, 77030
Contact: Daniel M Musher, M.D.     713-794-7384     dmusher@bcm.tmc.edu    
Contact: Nancy L Logan, M.A.     713-794-7384     njarrar@bcm.tmc.edu    
Principal Investigator: Daniel M Musher, M.D.            
Sponsors and Collaborators
VA Medical Center, Houston
Baylor College of Medicine
Investigators
Principal Investigator: Daniel M Musher, M.D. Baylor College of Medicine, Houston VA Medical Center
  More Information

No publications provided

Study ID Numbers: H-17555
Study First Received: March 16, 2006
Last Updated: March 16, 2006
ClinicalTrials.gov Identifier: NCT00304395     History of Changes
Health Authority: United States: Institutional Review Board

Keywords provided by VA Medical Center, Houston:
Community Acquired Pneumonia
CAP

Study placed in the following topic categories:
Respiratory Tract Infections
Respiratory Tract Diseases
Lung Diseases
Pneumonia

Additional relevant MeSH terms:
Respiratory Tract Infections
Respiratory Tract Diseases
Lung Diseases
Pneumonia

ClinicalTrials.gov processed this record on May 06, 2009