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Sponsors and Collaborators: |
University of Mississippi Medical Center Ohio State University |
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Information provided by: | University of Mississippi Medical Center |
ClinicalTrials.gov Identifier: | NCT00433355 |
The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS). Epstein Barr Virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown.
Condition |
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Chronic Fatigue Syndrome |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Studies on Epstein-Barr Virus as a Possible Etiological Agent for Chronic Fatigue Syndrome |
Enrollment: | 15 |
Study Start Date: | January 2007 |
Study Completion Date: | October 2008 |
Primary Completion Date: | August 2008 (Final data collection date for primary outcome measure) |
Epstein-Barr virus (EBV) is the etiological agent for heterophile positive infectious mononucleosis (IM). It is also an oncogenic herpes virus associated with African Burkitt's lymphoma (BL),nasopharyngeal carcinoma (NPC) and AIDS-associated B-cell lymphomas. EBV is also among a group of viruses that have been associated with chronic fatigue syndrome (CFS), although the etiology of CFS still remains unknown.Findings may lead to hypothesize that EBV enzymes, such as the dUTPase, have the capacity to induce immune dysregulation of the T-cell and NK cell responses and that this immune dysregulation produces immunopathology that results in the symptoms that we call CFS.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
18 y/o and above with history of CFS matched those without as to age and gender.
Inclusion Criteria:
Exclusion Criteria:
Note: We recruit participants in the Mississippi area who could come in our site to provide blood draw.
United States, Mississippi | |
University of Mississippi Medical Center | |
Jackson, Mississippi, United States, 39216-4505 |
Principal Investigator: | Gailen D Marshall, M.D., PhD | University of Mississippi Medical Center |
Responsible Party: | The University of Mississippi Medical Center ( Gailen D. Marshall, MD, PhD ) |
Study ID Numbers: | 2006-0265 |
Study First Received: | February 7, 2007 |
Last Updated: | March 18, 2009 |
ClinicalTrials.gov Identifier: | NCT00433355 History of Changes |
Health Authority: | United States: Institutional Review Board |
Chronic Fatigue Syndrome Epstein-Barr Virus |
Virus Diseases Signs and Symptoms Muscular Diseases Fatigue Neuromuscular Diseases |
Musculoskeletal Diseases Myalgic Encephalomyelitis Central Nervous System Diseases Encephalomyelitis Fatigue Syndrome, Chronic |
Fatigue Disease Nervous System Diseases Central Nervous System Diseases Encephalomyelitis Fatigue Syndrome, Chronic Virus Diseases |
Signs and Symptoms Muscular Diseases Pathologic Processes Musculoskeletal Diseases Neuromuscular Diseases Syndrome |