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| Sponsored by: |
USDA Grand Forks Human Nutrition Research Center |
|---|---|
| Information provided by: | USDA Grand Forks Human Nutrition Research Center |
| ClinicalTrials.gov Identifier: | NCT00620763 |
Purpose
The impact of protein sources such as beef as part of Western diet on calcium retention remains controversial. We propose to test the hypothesis that the positive effect of high protein intake (especially from meat protein)can offset the negative effect of protein-induced net acid load on bone metabolism and the retention of body calcium. Healthy postmenopausal women recruited from the community will consume two diets differing in meat protein and acid load for 7 weeks. Calcium retention from diets will be determined using a highly sensitive measurement of whole body retention of a calcium isotope added to the diet.
| Condition | Intervention |
|---|---|
|
Healthy |
Other: Controlled diet |
| Study Type: | Interventional |
| Study Design: | Prevention, Randomized, Open Label, Active Control, Crossover Assignment, Bio-availability Study |
| Official Title: | Calcium Retention in Postmenopausal Women as Influenced by Beef and Other Dietary Components That Induce an Acid Load |
| Enrollment: | 22 |
| Study Start Date: | January 2008 |
| Study Completion Date: | May 2008 |
| Primary Completion Date: | May 2008 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
A: Experimental
Dietary Intervention: High meat and high acid load diet followed by low meat and low acid load diet
|
Other: Controlled diet
High meat and high acid load diet followed by low meat and low acid load diet
|
|
B: Experimental
Dietary Intervention: Low meat and low acid load diet followed by high meat and high acid load diet
|
Other: Controlled diet
Low meat and low acid load diet followed by high meat and high acid load diet.
|
Eligibility| Ages Eligible for Study: | 40 Years to 75 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, North Dakota | |
| Grand Forks Human Nutrition Research Center | |
| Grand Forks, North Dakota, United States, 58202 | |
| Principal Investigator: | Jay Cao, PhD | USDA Grand Forks Human Nutrition Research Center |
More Information
| Responsible Party: | USDA Grand Forks Human Nutrition Research Center ( Jay Cao, Research Nutritionist ) |
| Study ID Numbers: | GFHNRC087, IRB-2000707-013 |
| Study First Received: | January 18, 2008 |
| Last Updated: | September 16, 2008 |
| ClinicalTrials.gov Identifier: | NCT00620763 History of Changes |
| Health Authority: | United States: Federal Government; United States: Institutional Review Board; United States: Food and Drug Administration |
|
Meat protein acid load calcium retention postmenopausal women |
|
Calcium, Dietary Healthy Urinary Retention |
