Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsored by: |
Centre Hospitalier Universitaire de Nice |
---|---|
Information provided by: | Centre Hospitalier Universitaire de Nice |
ClinicalTrials.gov Identifier: | NCT00821743 |
Disturbance of posture, gait and balance usually appear several years after Parkinson's disease (PD) onset. These axial signs, generally resistant to conventional drug and non-drug treatment, can generate a loss of autonomy and traumatic complications. Improvement of these axial signs by deep brain stimulation (DBS) of the pedunculo-pontin nucleus (PPN) has been described for a small number of patients. The objectives of the present prospective monocentric pilot study are to determine the optimal stimulation parameters of PPN-DBS, to evaluate the long term tolerance and the effect of PPN-DBS on axial signs and quality of life in five patients with severe PD. The use of detailed clinical rating scales and quantitative computer-based gait analysis will allow to identify the optimal stimulation parameters and relevant clinical efficacy parameters, mandatory for the design of further comparative large-scale studies.
Condition | Intervention | Phase |
---|---|---|
Parkinson Disease |
Device: Deep brain stimulation electrode |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment, Safety/Efficacy Study |
Official Title: | Study of Deep Brain Stimulation of the Pedunculo-Pontin Nucleus (PPN) for the Treatment of Gait and Balance Disturbances in Patients With Parkinson's Disease (PPN-GAB-PARK Study) |
Estimated Enrollment: | 5 |
Study Start Date: | February 2009 |
Estimated Study Completion Date: | February 2010 |
Estimated Primary Completion Date: | February 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
1
The DBS electrodes (model 3389, Medtronic) will be stereotactically implanted bilaterally in the PPN, according to the technique usually used for STN-DBS, and connected to the subcutaneously implanted stimulator (Kinetra, Medtronic).
|
Device: Deep brain stimulation electrode
The DBS electrodes (model 3389, Medtronic) will be stereotactically implanted bilaterally in the PPN, according to the technique usually used for STN-DBS, and connected to the subcutaneously implanted stimulator (Kinetra, Medtronic).
|
Parkinson's disease (PD) is a neurodegenerative disorder with an association of akinesia, rigidity and tremor, but also so-called "axial" motor signs (disturbance of posture, gait and balance) that usually appear after several years of disease evolution. These axial signs, generally resistant to drug treatment and deep brain stimulation (DBS) of subthalamic nucleus (STN), can generate a loss of autonomy and traumatic complications due to frequent falls. An improvement of axial signs by DBS of the pedunculo-pontin nucleus (PPN) has been described for a small number of patients. Nevertheless, this effect needs to be confirmed in more patients and there is need for complementary knowledge, including optimal stimulation modalities.
The primary objective of the current prospective monocentric pilot study is to determine the optimal stimulation parameters (site of stimulation, frequency, amplitude) of PPN-DBS in patients with severe PD. Secondary objectives are 1) to confirm the effect of PPN-DBS on disturbance of posture, balance and gait; 2) to evaluate long term tolerance of this technique; 3) to determine the components of gait that are most improved by PPN-DBS; 4) to evaluate unilateral versus bilateral stimulation; 5) to evaluate the effects of PPN-DBS on other PD symptoms; 6) to determine the impact of PPN-DBS on quality of life. Five patients fulfilling the following criteria, will be included: age between 18 and 70 years, idiopathic PD for more than 5 years, predominant axial motor signs (disturbance of gait and balance, falls, freezing of gait) responsible for disability in daily living and resistant to optimal treatment. The DBS electrodes (model 3389, Medtronic) will be stereotactically implanted bilaterally in the PPN, according to the technique usually used for STN-DBS, and connected to the subcutaneously implanted stimulator (Kinetra, Medtronic). After the surgery, the study will comprise two phases: a 6-month phase dedicated to optimisation of the stimulation parameters (including systematic evaluation of defined parameters); followed by a phase of evaluation, that will compare, in a double-blind setting, 4 conditions (right unilateral, left unilateral, bilateral and off stimulation). Efficacy of PPN-DBS will be evaluated by clinical rating scales quantifying motor disturbance, cognitive function and quality of life, and by the means of computer-based measure of gait and balance (system Gaitrite and Vicon). Expected results are 1) an improvement of gait, postural and balance disturbance, due to PPN-DBS. 2) Identification of the optimal PPN-DBS parameters, improving most the axial PD symptoms, will allow to abbreviate the adjustment period, by using as default setting these parameters when turning on the stimulator for the first time; 3) Identification of the axial signs which are the most improved will allow to select patients that could most benefit from PPN-DBS 4) The use of diverse specific rating scales and quantitative gait analysis will allow to determine the most relevant clinical criteria to be evaluated in further studies. Thus, this project will allow to obtain data (selection criteria, relevant rating scales, optimal stimulation parameters) mandatory for the construction of further comparative large-scale studies, if the efficacy of PPN-DBS was confirmed by the present study.
Ages Eligible for Study: | 18 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Non-inclusion criteria
Contact: Denys FONTAINE, PhD | 04 92 03 84 50 | fontaine.d@chu-nice.fr |
Contact: Caroline BAYREUTHER, PhD | 04 92 03 78 96 | bayreuther.c@chu-nice.fr |
France | |
Neurology, Neurosugery of Nice University Hospital | |
nice, France, 06000 |
Principal Investigator: | Denys FONTAINE, PhD | Department of neurosurgery, CHU de Nice |
Responsible Party: | CHU de Nice ( Département de la Recherche Clinique et de l'Innovation ) |
Study ID Numbers: | PPN-GAB-PARK study |
Study First Received: | January 12, 2009 |
Last Updated: | January 12, 2009 |
ClinicalTrials.gov Identifier: | NCT00821743 History of Changes |
Health Authority: | France: Afssaps - French Health Products Safety Agency; France: French Data Protection Authority; France: Institutional Ethical Committee |
Ganglion Cysts Movement Disorders Parkinson Disease Basal Ganglia Diseases |
Central Nervous System Diseases Parkinsonian Disorders Neurodegenerative Diseases Brain Diseases |
Movement Disorders Parkinson Disease Nervous System Diseases Basal Ganglia Diseases |
Central Nervous System Diseases Parkinsonian Disorders Neurodegenerative Diseases Brain Diseases |