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| Sponsors and Collaborators: |
Zhejiang University Taizhou Hospital |
|---|---|
| Information provided by: | Zhejiang University |
| ClinicalTrials.gov Identifier: | NCT00820378 |
Purpose
Aortic aneurysms are the major disease processes affecting the aorta and becoming a relatively common cause of death because of rupture or dissection.
The most common location for aneurysms is the infrarenal abdominal aorta, followed by the ascending thoracic aorta. Unlike coronary heart disease, the incidence of abdominal aortic aneurysm (AAA) in the United States and Europe has been increasing, and this increase may not be due to higher levels of screening for this condition alone. Aortic diameter is central to the diagnosis of aortic aneurysm. Furthermore, it was demonstrated that non-AAA patients with an enlarged diameter of the infrarenal aortic diameter are also at high risk for all-cause mortality. And aortic root dimension was associated with several coronary artery disease (CHD) risk factors and measures of subclinical disease and was predictive of incident congestive heart failure (CHF), stroke, cardiovascular disease (CVD) mortality, and all-cause mortality, but not of incident MI. Up to now, there are limited studies on the epidemiology of aortic diameter, especially in Chinese population.
| Condition | Intervention |
|---|---|
|
Vascular Disease Diabetes Hypertension Hyperlipidemia |
Other: No special interventioin |
| Study Type: | Observational |
| Study Design: | Case-Crossover, Cross-Sectional |
| Official Title: | Epidemiology of Aortic Dimensions in Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors |
| Estimated Enrollment: | 2000 |
| Study Start Date: | January 2009 |
| Estimated Study Completion Date: | December 2015 |
| Estimated Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
atherosclerosis
Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors
|
Other: No special interventioin
Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment. The aortic dimensions were assessed at end-diastole at the different levels:
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The purpose of this study was to analyze the size of the entire aorta at different anatomic levels in a large group of Chinese population with clinically evident arterial disease or cardiovascular risk factors to further explored the risk factors and potential alternative pathomechanisms for the development of aortic dilatation. Comprehensive transthoracic M-mode, 2-dimensional, and Doppler echocardiographic studies will be performed using commercially available equipment. The aortic dimensions were assessed at end-diastole at the different levels: (1) the annulus, (2) the mid-point of the sinuses of Valsalva, (3) the sinotubular junction, (4) the ascending aorta at the level of its largest diameter, (5) the transverse arch, (6) the descending aorta posterior to the left atrium, and (7) the abdominal aorta just distal to the origin of the renal arteries. The extension of dilation is defined as the number of dilated aortic segments. The relations among aortic dimensions and clinical characteristics will be assessed by multiple regression analysis. The current study was to determine the association of risk factors of CVD and atherosclerosis diseases with aortic dimension in Chinese patients with clinical event atherosclerotic disease or risk factors of atherosclerotic disease.
Eligibility| Ages Eligible for Study: | 40 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Chinese population with clinically evident arterial disease or cardiovascular risk factors
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Xiao-feng Chen, MD. | 86-13656680890 | zjxiaofengchen@hotmail.com |
| China, Zhejiang | |
| Second Affiliated Hospital of Zhejiang University College of Medicine | Recruiting |
| Hangzhou, Zhejiang, China, 317000 | |
| Contact: Zhao-xia Pu 86-13989488402 zhaoxiapu@163.com | |
| Principal Investigator: Zhao-xia Pu, MD | |
| Taizhou Hospital, Wenzhou Medical College | Recruiting |
| Taizhou, Zhejiang, China, 317000 | |
| Contact: Li-jiang Tang 86-13606655138 taizhoutang@hotmail.com | |
| Principal Investigator: Li-jiang Tang | |
| Study Chair: | Jian-an Wang | Second Affiliated Hospital of Zhejiang University College of Medicine |
| Principal Investigator: | Li-jiang Tang | Taizhou Hospital, Wenzhou Medical College |
| Principal Investigator: | Xiao-feng Chen | Second Affiliated Hospital of Zhejiang University College of Medicine |
| Principal Investigator: | Zhao-xia Pu | Second Affiliated Hospital of Zhejiang University College of Medicine |
| Principal Investigator: | Xian-fang Lin | Taizhou Hospital, Wenzhou Medical College |
More Information
| Responsible Party: | Second Affiliated Hospital, College of Medicine, Zhejiang University ( Jian-an Wang/Prof. ) |
| Study ID Numbers: | EPAD |
| Study First Received: | January 8, 2009 |
| Last Updated: | January 12, 2009 |
| ClinicalTrials.gov Identifier: | NCT00820378 History of Changes |
| Health Authority: | China: Ethics Committee |
|
Aortic dimension Atherosclerosis Vascular disease Risk factors |
|
Atherosclerosis Metabolic Diseases Hyperlipidemias Diabetes Mellitus Vascular Diseases |
Metabolic Disorder Dyslipidemias Lipid Metabolism Disorders Hypertension |
|
Metabolic Diseases Hyperlipidemias Vascular Diseases Cardiovascular Diseases |
Dyslipidemias Lipid Metabolism Disorders Hypertension |
