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Sponsored by: |
Centre Hospitalier Universitaire de Nice |
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Information provided by: | Centre Hospitalier Universitaire de Nice |
ClinicalTrials.gov Identifier: | NCT00820287 |
Testis cancer with germ cells is the most frequent cancer of young men and its incidence is in constant increase in many industrialized countries, as in France. An increased risk of developing testis cancer has been described in patients with testicular ectopia history and testicular cancer history (controlateral testicular cancer) and more recently suggested in a population of hypofertile men with altered spermatogenesis. To a better understanding of this risk, an attempt of characterization of this group of patients has been proposed in the present work.
The general objective of this project is to characterize morphological and molecular markers of hypofertility which could serve as predictive markers of testis malignant transformation.
In this project conducted in 3 establishments, the investigators propose:
These approaches would allow to identify, in this population of hypofertile patients, subgroups of men who could develop tumours with germ cells, and subsequently to propose potential biomarkers for testis cancer. A more clinical observation of these subgroups will be also proposed.
Condition | Intervention |
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Testicular Cancer |
Procedure: Biopsy of testicular tumor |
Study Type: | Interventional |
Study Design: | Diagnostic, Open Label, Uncontrolled, Single Group Assignment |
Official Title: | Identification of Predictive Markers for Testis Cancer in a Population of Men With High Risk |
Estimated Enrollment: | 225 |
Study Start Date: | September 2005 |
Ages Eligible for Study: | 18 Years to 35 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Daniel Chevallier, MDPHD | 0492037831 | chevallier.d@chu-nice.fr |
France | |
CHU de Nice | Recruiting |
Nice, France, 06000 | |
Contact: daniel chevallier, MDPHD 0492037831 chevallier.d@chu-nice.fr |
Responsible Party: | CHU de Nice ( DRCI / Melanie Bonnard ) |
Study ID Numbers: | APN 2004 |
Study First Received: | January 9, 2009 |
Last Updated: | January 9, 2009 |
ClinicalTrials.gov Identifier: | NCT00820287 History of Changes |
Health Authority: | France: Direction Générale de la Santé; France: Afssaps - French Health Products Safety Agency |
Testicular cancer incidence young men |
Testicular Cancer Genital Neoplasms, Male Gonadal Disorders Testicular Diseases Endocrine System Diseases |
Urogenital Neoplasms Endocrinopathy Testicular Neoplasms Genital Diseases, Male Endocrine Gland Neoplasms |
Neoplasms Neoplasms by Site Genital Neoplasms, Male Gonadal Disorders Testicular Diseases |
Endocrine System Diseases Urogenital Neoplasms Testicular Neoplasms Genital Diseases, Male Endocrine Gland Neoplasms |