About   Help   FAQ
Phenotypes, Alleles & Disease Models
The Phenotypes/Alleles project in MGI enables access to spontaneous, induced, and genetically-engineered mutations and their strain-specific phenotypes.
Access Data
Search for mutations or QTL based on phenotype, human disease, mutation type, gene, or genome location.
Phenotypes, Alleles & Disease Models Query
Search for a phenotype term to find relevant mutant genotypes.
Mammalian Phenotype (MP) Browser
Search for a human disease term to find mouse models.
Human Disease (OMIM) Browser
Search for candidate genes for a given phenotype within a genomic interval.
Genes & Markers Query
Input a list of genes and retrieve associated alleles and phenotypes.
Batch Query
Submit a new allele, mutation, or transgene and receive official nomenclature and an MGI accession identifier.
Allele Nomenclature Form
Describe characteristics of spontaneous, induced, or genetically engineered mutations already entered in MGI
Phenotype Data Submission Form
View guides to proper naming of alleles and mutations.
Quick Guide to Allele Nomenclature
Complete Guide to Nomenclature
FAQs
How do I...
.. find mutations in a specific gene? FAQ
.. find mouse models for a human disease or condition? FAQ
.. find mutations that cause a specific combination of phenotypes? FAQ
.. find all of one kind of allele (e.g. cre transgenes, LoxP/Frt-flanked alleles, etc.)? FAQ
More FAQs
Phenotypes, Alleles & Disease Models Includes
31 Jan 2009
21,245
Mutant alleles
8,323
Genes with mutant alleles
28,283
Genotypes with phenotype annotations
896
Human diseases with one or more mouse models
More...
Phenotype News
18 Sept 2008

Phenotype pages have been redesigned and new features added in the MGI 4.12 release.

  • The Phenotype section of each Allele Detail Page now includes two distinct views of phenotype data.
  • A new section, Phenotype Summary, presents data in a matrix format that allows easy comparison of phenotypes across genotypes. Users can compare effects of different allelic combinations (homozygotes, heterozygotes, conditionals, complex allelic combinations, etc.), different genetic backgrounds with the same allelic combinations, and quickly view the range of phenotypic effects observed for a given allele. This phenotype matrix view is presented first with an axis of high level terms like "hematopoietic system" and gives the user the option to expand that section into more specific annotated phenotypic terms (anemia, increased mast cell number, etc.).
  • In addition, the ability to pop up individual windows that contain the phenotype and disease model for a single genotype is available from the Phenotype Summary. This can facilitate comparisons across mutants for a single gene, as well as among mutants for different genes.
  • The Phenotypic Data by Genotype section presents a table of genotypes that can be expanded to show complete phenotype annotation, preserving the data format previously provided. For each genotype listed, users can expand the display to show the full phenotype detail for a given genotype (or for all genotypes), as well as the disease model annotations.
  • To see an example of a the redesigned allele detail page, check this record for one of the targeted mutations of the endoglin gene, Engtm1Mle. For additional information, see the Allele Tour displaying the basics of the new phenotype formats.
MGI-Mouse Phenotypes, Alleles & Disease Models: Other Links - Phenotypes, Alleles & Disease Models: Other Links
Knockout Mice Other useful links

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/31/2009
MGI_4.2
Web browser compatibility
The Jackson Laboratory