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Link to the citations for PA-09-061 - Vulnerable Dendrites and Synapses in Aging and Alzheimer’s Disease (R01)

Link for PA-09-061


Almeida CG, Takahashi RH, Gouras GK. J Neurosci. 2006 Apr 19;26 (16):4277-88. Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. PMID: 16624948.

Barrett LE, Sul JY, Takano H, Van Bockstaele EJ, Haydon PG, Eberwine JH. Nat Methods. 2006 Jun;3(6):455-60. Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor. PMID: 16721379.

Burke SN, Barnes CA. Nat Rev Neurosci. 2006 Jan;7(1):30-40. Neural plasticity in the ageing brain. PMID: 16371948.

Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR. Brain. 2006 Nov;129(Pt 11):2992-3005. Epub 2006 Jul 14. Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology. PMID: 16844716.

Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L. J Neurosci. 2004 May 12;24(19):4692-7. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. PMID: 15140940.

DeKosky ST, Scheff SW. Ann Neurol. 1990 May;27(5):457-64. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. PMID: 2360787.

Eckermann K, Mocanu MM, Khlistunova I, Biernat J, Nissen A, Hofmann A, Schönig K, Bujard H, Haemisch A, Mandelkow E, Zhou L, Rune G, Mandelkow EM. J Biol Chem. 2007 Oct 26;282(43):31755-65. Epub 2007 Aug 23. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. PMID: 17716969.

Geinisman Y, de Toledo-Morrell L, Morrell F, Persina IS, Rossi M. Hippocampus. 1992 Oct;2(4):437-44. Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. PMID: 1308200.

Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M. J Neurosci. 2006 Feb 1;26(5):1343-54. Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. PMID: 16452658.

Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5161-6. Epub 2006 Mar 20. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. PMID: 16549764.

Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. Neuron. 2008 Jun 12;58(5):681-93. ApoE promotes the proteolytic degradation of Abeta. PMID: 18549781.

Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. J Neurosci. 2004 Nov 10;24(45):10191-200. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. PMID: 15537891.

Lanz TA, Carter DB, Merchant KM. Neurobiol Dis. 2003 Aug;13(3):246-53. Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. PMID: 12901839.

Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schönig K, Bujard H, Mandelkow E, Zhou L, Rune G, Mandelkow EM. J Neurosci. 2008 Jan 16;28(3):737-48. The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. PMID: 18199773.

Moolman DL, Vitolo OV, Vonsattel JP, Shelanski ML. J Neurocytol. 2004 May;33(3):377-87. Dendrite and dendritic spine alterations in Alzheimer models. PMID: 15475691.

Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006 Oct 4;26(40):10129-40. PMID: 17021169.

Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. Eur J Neurosci. 2006 Jan;23(1):251-60. PMID: 16420434.

Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J. Synapse formation and function is modulated by the amyloid precursor protein. J Neurosci. 2006 Jul 5;26(27):7212-21. PMID: 16289476.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J Neurosci. 2005 Jul 20;25(29):6755-64. PMID: 16033885.

Scheff SW, Price DA, Schmitt FA, Mufson EJ. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 2006 Oct;27(10):1372-84. Epub 2005 Nov 9. PMID: 16289476.

Schönheit B, Glöckner F, Ohm TG. Apolipoprotein E polymorphism and dendritic shape in hippocampal interneurons. Neurobiol Aging. 2007 May;28(5):677-86. Epub 2006 Oct 4. PMID: 17023092.

Selkoe DJ. Alzheimer's disease is a synaptic failure. Science. 2002 Oct 25;298(5594):789-91. PMID: 12399581

Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug;14(8):837-42. Epub 2008 Jun 22. PMID: 18568035.

Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci. 2005 Aug 3;25(31):7278-87. PMID: 16079410.

Steward O, Schuman EM. Compartmentalized synthesis and degradation of proteins in neurons. Neuron. 2003 Oct 9;40(2):347-59. PMID: 14556713.

Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol. 1997 Aug;56(8):933-44. PMID: 9258263.

Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991 Oct;30(4):572-80. PMID: 1789684.

Wilson IA, Ikonen S, Gallagher M, Eichenbaum H, Tanila H. Age-associated alterations of hippocampal place cells are subregion specific. J Neurosci. 2005 Jul 20;25(29):6877-86. PMID: 16033897.

Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM.  Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 2006 Feb;9(2):234-42. Epub 2006 Jan 15. PMID: 16415866.

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