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Key Points
- Polycythemia vera (PV) is a rare blood disease in which your body
makes too many red blood cells.
- The extra red blood cells make your blood thicker than normal. As a result,
blood clots can form more easily and block blood flow through your arteries
and veins. This can lead to heart attack and stroke.
- Thicker blood also flows more slowly to all parts of your body, preventing
your organs from getting enough oxygen. This can cause other serious
complications, such as as angina (chest pain) and heart failure.
- PV also is known as primary polycythemia. A mutation, or change, in the
JAK2 gene is the major cause of PV. This gene makes an important protein
that helps the body produce blood cells. What causes the change in the JAK2 gene isn't known.
- Another type of polycythemia, called secondary polycythemia, isn't related to
the JAK2 gene. Long-term exposure to low oxygen levels causes secondary polycythemia.
- PV is a very rare blood disease. It's more common in adults
older than 60, and it's slightly more common in men.
- The most common signs and symptoms of PV are headache, dizziness,
weakness, shortness of breath, feelings of pressure or fullness on the
left side of the abdomen (due to an enlarged spleen), double or blurred
vision and blind spots, itching, reddened face, a burning feeling on the
skin (especially the hands and feet), bleeding from the gums, heavy bleeding
from small cuts, unexplained weight loss, and fatigue (tiredness).
- PV may not cause signs or symptoms for years. Thus, the disease often is found
during routine blood tests done for other reasons. PV is diagnosed based on your
signs and symptoms, age and overall health, medical history, a physical exam, and test results.
- PV can't be cured. However, treatments can help control the disease and its
complications. PV is treated with procedures, medicines, and other methods.
- The goals of treating PV are to control your symptoms and reduce the risk of
complications due to thickened blood and blood clots.
- Primary polycythemia can't be prevented. However, with proper treatment, you
can prevent or delay symptoms and complications. Avoiding things that deprive
your body of oxygen for long periods may prevent some cases of secondary polycythemia.
- If you have PV, you will need lifelong medical care for the disease. Talk to your
doctor about how often to schedule followup visits. Routine care will allow your
doctor to detect any changes with your PV and treat them early, if needed. Follow your
treatment plan and take all of your medicines as your doctor prescribes.
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