How Is Aplastic Anemia Treated?
Treatments for aplastic anemia include
blood
transfusions,
blood
and marrow stem cell transplants, and medicines. These treatments can
prevent or limit complications, relieve symptoms, and improve quality of
life.
In some cases, a cure may be possible. Blood and
marrow stem cell transplants may cure the disorder in people who are eligible
for a transplant. Removing a known cause of aplastic anemia, such as exposure
to a toxin, also may cure the condition.
Who Needs Treatment
People who have mild or moderate aplastic anemia may
not need treatment as long as the condition doesnt get worse. People who
have severe aplastic anemia need medical treatment right away to prevent
complications.
People who have very severe aplastic anemia need
emergency medical care in a hospital. Very severe aplastic anemia can be fatal
if it's not treated right away.
Blood Transfusions
People who have aplastic anemia may need blood
transfusions to keep their blood cell counts at acceptable levels.
A blood transfusion is a common procedure in which
blood is given to you through an intravenous (IV) line in one of your blood
vessels. Transfusions require careful matching of donated blood with the
recipients blood.
Blood transfusions help relieve the symptoms of
aplastic anemia, but theyre not a permanent treatment.
Blood and Marrow Stem Cell Transplants
A blood and marrow stem cell transplant replaces
damaged stem cells with healthy ones from another person (a donor).
During the transplant, which is like a blood
transfusion, you get donated stem cells through a tube placed in a vein in your
chest. Once the stem cells are in your body, they travel to your bone marrow
and begin making new blood cells.
Blood and marrow stem cell transplants often cure
aplastic anemia in people who are eligible for this type of transplant. The
transplant works best in children and young adults with severe aplastic anemia
who are in good health and who have matched donors.
Older people may be less able to handle the
treatments needed to prepare the body for the transplant. Theyre also
more likely to have complications after the transplant.
If you have aplastic anemia, talk to your doctor
about whether a bone and marrow stem cell transplant is an option for you.
Medicines
If you have aplastic anemia, your doctor may
prescribe medicines to:
- Stimulate your bone marrow
- Suppress your immune system
- Prevent and treat infections
Medicines To Stimulate Bone Marrow
Man-made versions of substances that occur naturally
in the body can stimulate the bone marrow to make more blood cells. Examples of
these types of medicines include erythropoietin (e-RITH-ro-PO-e-tin) and
colony-stimulating factors.
These medicines have some risks. You and your doctor
will work together to decide whether the benefits of these medicines outweigh
the risks. If this treatment works well, it can help you avoid the need for
blood transfusions.
Medicines To Suppress the Immune System
Research suggests that some cases of aplastic anemia
may occur because the bodys immune system attacks its own cells by
mistake. For this reason, your doctor may prescribe medicines to suppress your
immune system.
These medicines can allow your bone marrow to start
making blood cells again. These medicines also may help you avoid the need for
blood transfusions.
Medicines that suppress the immune system dont
cure aplastic anemia. However, they can relieve its symptoms and reduce its
complications.
These medicines often are used for people who
arent eligible for a bone and marrow stem cell transplant or who are
waiting for a transplant.
Three medicinesoften given togethercan
suppress the bodys immune system. They are antithymocyte globulin (ATG),
cyclosporine, and methylprednisolone.
It may take a few months to notice the effects of
these medicines. Most often, as blood cell counts rise, symptoms lessen. Blood
cell counts in people who respond well to these medicines usually dont
reach normal levels. However, the blood cell counts often are high enough to
allow people to do their normal activities.
People who have aplastic anemia may need long-term
treatment with these medicines.
Medicines that suppress the immune system can have
side effects. They also may increase the risk of developing leukemia
(lu-KE-me-ah) or myelodysplasia (MI-e-lo-dis-PLA-ze-a; MDS). Leukemia is a
cancer of the blood cells. MDS is a condition in which the bone marrow makes
too many faulty blood cells.
Medicines To Prevent and Treat Infections
People who have aplastic anemia may be at risk for
infections due to a low number of white blood cells. Your doctor may prescribe
antibiotic and antiviral medicines to prevent and treat infections. |