Anticonvulsants, including
phenytoin and
carbamazepine,
lamotrigine, and
sodium valproate may be prescribed for treatment of Isaac's syndrome and can be used in combination.
[1][2][4] These treatments usually provide significant relief from the stiffness, muscle spasms, and pain associated with Isaac's syndrome. In patients whose symptoms are debilitating or refractory to symptomatic therapy, immunomodulatory therapies may be tried.
[4] Plasma exchange may provide short-term relief for patients with some forms of the acquired disorder.
[1][4] Clinical improvement lasts about 6 weeks.
[4] Single case studies suggest that intravenous infusions of immunoglobulins (IvIg therapy) can also help. However there are no good trials of long-term oral immunosuppression. Prednisolone, with or without azathioprine or methotrexate, has been reported as useful in selected patients.[4]