Substances |
PDN Description |
Status(1) |
Aldrin/Dieldrin
|
- Dose-response data in animals for intermediate(2)-duration oral
exposure
- Bioavailability from soil
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
- Exposure levels in children
|
Filled |
Arsenic
|
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
- Bioavailability from soil
|
Filled |
Asbestos |
- Potential candidate for subregistry of exposed persons
- Improved analytical methods for screening samples and determining the
chemical structure of asbestos fibers. Also, techniques are needed to
normalize studies in which different analytical methods were employed
|
Filled |
Benzene |
- Epidemiologic studies on the health effects of benzene (Special emphasis
end points include immunotoxicity)
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Beryllium |
- Analytical methods to determine environmental speciation
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Cadmium |
- Analytical methods for biological tissues and fluids and environmental
media
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Carbon tetrachloride |
- Immunotoxicology battery of tests via oral exposure
- Half-life in soil
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Chlordane
|
- Oral multigenerational studies to evaluate reproductive toxicity
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations potentially exposed to chlordane
- Exposure levels in children
|
Filled |
Chlorinated dibenzo-p-dioxins (CDDs) |
- Exposure levels in humans (adults) living near hazardous waste sites
- Exposure levels in children
|
Filled |
Chloroform |
- Dose-response data in animals for intermediate-duration oral exposure
- Epidemiologic studies on the health effects of chloroform (Special
emphasis end points include cancer, neurotoxicity, reproductive and
developmental toxicity, hepatotoxicity, and renal toxicity)
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Chromium
|
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
- Dose-response data in animals for acute-duration exposure to chromium (VI)
via oral exposure
- Dose-response data in animals for intermediate-duration exposure to
chromium (VI) via oral exposure
- Multigeneration reproductive toxicity study via oral exposure to chromium
(VI)
- Prenatal developmental toxicity study via oral exposure to chromium (VI)
|
Filled |
Cyanide
|
- Evaluation of the environmental fate of cyanide in soil
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
1,2-Dibromoethane |
- Immunotoxicity battery studies via oral exposure
|
Filled |
1,1-Dichloroethene |
- Dose-response data in animals for acute(3)-duration exposure by the
inhalation route
- Dose-response data in animals for chronic(4)-duration exposure by the
inhalation route
|
Filled |
1,2-Dichloroethane |
- Neurotoxicology battery of tests following inhalation exposure
|
Filled |
1,1-Dichloroethene |
- Dose-response data in animals for acute-duration exposure by the oral
route
- Dose-response data in animals for intermediate-duration exposure by the
oral route
- Prenatal developmental toxicity studies following oral exposure
|
Filled |
DDT |
- Epidemiologic studies on the health effects of DDT, DDD, and DDE (Special
emphasis end points include immunotoxicity, and reproductive and
developmental toxicity)
- Bioavailability and bioaccumulation from soil
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Di(2-ethylhexyl) phthalate
|
- Epidemiologic studies on the health effects of DEHP
- Dose-response data in animals for acute-duration oral exposure
- Dose-response data in animals for intermediate-duration oral exposure
- Multigeneration reproductive toxicity study via oral exposure
- Comparative toxicokinetic studies (Studies designed to examine how
primates metabolize and distribute DEHP as compared with rodents via oral
exposure)
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Di-n-butyl phthalate |
- Dose-response data in animals for acute- duration exposure via the oral
route
- In vivo genotoxicity studies
- Environmental fate of di-n-butyl phthalate in environmental media
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Disulfoton
|
- Immunotoxicology testing battery following oral exposure
|
Filled |
Endrin/endrin aldehyde |
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Ethylbenzene |
- Dose-response data for acute-duration exposure by the inhalation route
- Dose-response data for chronic-duration exposure by the inhalation route
- Dose-response data for intermediate-duration exposure by the oral route
- Multigeneration toxicity study examining reproductive end points and
indicators of endocrine disruption following inhalation exposure
- Studies for comparative toxicokinetics
- Exposure levels in humans living near hazardous waste sites
- Exposure levels in children
|
Filled |
Heptachlor/
heptachlor epoxide
|
- Multigeneration reproductive toxicity studies via the oral route of
exposure
- Prenatal developmental toxicity studies via the oral route of exposure
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
- Dose-response animal data for acute- and intermediate-duration oral
exposures, including immunopathology
|
Filled |
Hexachloro-cyclohexane (α, β, γ, and δ) |
- Dose-response data for chronic-duration oral exposure
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Lead |
- Mechanistic studies on the neurotoxic effects of lead
- Analytical methods for tissue levels
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Manganese |
- Dose-response data for acute- and intermediate-duration oral exposures
(the intermediate-duration study should include reproductive histopathology
and an evaluation of immunologic parameters including manganese effects on
plaque-forming cells (SRBC), surface markers (D4:D8 ratio), and delayed
hypersensitivity reactions)
- Toxicokinetic studies on animals to investigate uptake and absorption,
relative uptake of differing manganese compounds, metabolism of manganese,
and interaction of manganese with other substances following oral exposure
- Epidemiological studies on the health effects of manganese (Special
emphasis end points include neurologic, reproductive, developmental,
immunologic, and cancer)
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Mercury |
- Multigeneration reproductive toxicity study via oral exposure
- Dose-response data in animals for chronic-duration oral exposure
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Methoxychlor
|
- Evaluate neurologic effects after long-term, low-level oral exposure
|
Filled |
Methylene chloride |
- Dose-response data in animals for acute- and intermediate-duration oral
exposure. The intermediate-duration study should include extended
reproductive organ histopathology, neuropathology, and immunopathology
- Prenatal developmental toxicity study via the oral route
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled(5) |
Nickel |
- Epidemiologic studies on the health effects of nickel (Special emphasis
end points include reproductive toxicity)
- Prenatal developmental toxicity study via the oral route
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Pentachlorophenol |
- Exposure levels in humans (adults) living near hazardous waste sites
- Exposure levels in children through play activities near contaminated
environmental media
|
Filled |
Polychlorinated
biphenyls (PCBs) |
- Epidemiologic studies on the health effects of PCBs (Special emphasis end
points include immunotoxicity, gastrointestinal toxicity, liver toxicity,
kidney toxicity, thyroid toxicity, and reproductive/developmental toxicity)
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
- Chronic toxicity and oncogenicity via oral exposure(6)
- Aerobic PCB biodegradation in sediment(6)
- PCB congener analysis(6)
|
Filled |
Polycyclic aromatic hydrocarbons (PAHs)
(Includes 15 substances)
|
- Dose-response data in animals for intermediate-duration oral exposures.
The intermediate-duration study should include extended reproductive organ
histopathology and immunopathology
- Prenatal developmental toxicity study via inhalation or oral exposure
- Mechanistic studies on PAHs, on how mixtures of PAHs can influence the
ultimate activation of PAHs, and on how PAHs affect rapidly proliferating
tissues
- Dose-response data in animals for acute- and intermediate-duration
inhalation exposures. The intermediate-duration study should include
extended reproductive organ histopathology and immunopathology
- Epidemiologic studies on the health effects of PAHs (Special emphasis end
points include cancer, dermal, hemolymphatic,and hepatic toxicity)
- Exposure levels in humans (adults) living near hazardous waste sites and
other populations, such as exposed workers
- Exposure levels in children
|
Filled |
Selenium |
- Epidemiologic studies on the health effects of selenium (Special emphasis
end points include cancer, reproductive and developmental toxicity, hepatotoxicity, and adverse skin effects)
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Tetrachloroethylene |
- Dose-response data in animals for acute-duration oral exposure, including
neuropathology and demeanor, and immunopathology
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Toluene |
- Dose-response data in animals for acute- and intermediate-duration oral
exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immune system
- Comparative toxicokinetic studies (Characterization of absorption,
distribution, and excretion via oral exposure)
- Mechanism of toluene-induced neurotoxicity
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Trichloroethylene |
- Dose-response data in animals for acute-duration oral exposure
- Epidemiologic studies on the health effects of trichloroethylene (Special
emphasis end points include cancer, hepatotoxicity, renal toxicity,
developmental toxicity, and neurotoxicity)
- Exposure levels in humans living near hazardous waste sites and other
populations, such as exposed workers
|
Filled |
Vinyl
chloride |
- Dose-response data in animals for acute-duration inhalation exposure
- Multigeneration reproductive toxicity study via inhalation
- Prenatal developmental toxicity study via inhalation
|
Filled |
Xylenes |
- Dose-response data for chronic-duration exposure by the oral route. This
study should be done in conjunction with the neurotoxicology battery of
tests
- Prenatal developmental toxicity study that includes neurodevelopmental end
points following oral exposure
- Exposure levels in children
|
Filled |
Zinc |
- Dose-response data in animals for acute- and intermediate-duration oral
exposures. The intermediate-duration study should include an extended histopathologic evaluation of the immunologic and neurologic systems
- Multigeneration reproductive toxicity study via oral exposure
|
Filled |