Genetic and Rare Diseases Information Center (GARD)


Other names people use for this condition
  • Miliaria, apocrine
  • Apocrine miliaria
  • Fox-Fordyce syndrome

Fox-Fordyce disease
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Fox-Fordyce disease is a chronic skin disease most common in women aged 13-35 years.[1] It is characterized by the development of intense itching in the underarm area, the pubic area, and around the nipple of the breast as a result of  perspiration which becomes becomes trapped in the sweat gland and surrounding areas.[2]  The cause is unknown, but heat, humidity, and stress appear to be exacerbating factors. Retinoids, antibiotics, and immunosuppressants have had limited success in controlling the symptoms.[1] 

References
  1. White SW, Gorman CR. Fox-Fordyce Disease. eMedicine. January 12, 2007 Available at: http://emedicine.medscape.com/article/1070560-overview. Accessed March 30, 2009.
  2. Fox Fordyce Disease. National Organization for Rare Disorders (NORD). 2000 Available at: http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Fox%20Fordyce%20Disease. Accessed March 30, 2009.

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