Fibrodysplasia ossificans progressiva
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Fibrodysplasia ossificans progressiva (FOP) is a disorder in which muscle tissue and connective tissue such as tendons and ligaments are gradually replaced by bone (ossified), forming bone outside the skeleton (extra-skeletal or heterotopic bone) that constrains movement. This process generally becomes noticeable in early childhood, starting with the neck and shoulders and proceeding down the body and into the limbs. FOP is caused by mutations in the ACVR1 gene. This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. Most cases result from new mutations in the gene.[1] At this time, there is no teatment for FOP.[2]
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International Fibrodysplasia Ossificans Progressiva Association
PO Box 196217
Winter Springs FL 32719
Phone: 407-365-4194
Fax: 407-365-3213
Email: together@ifopa.org
Web: www.ifopa.org
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