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Epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population.
Journal of Infectious Diseases 2004;189:46-50.
Tarkowski TA, Koumans EH, Sawyer M, Pierce A, Black CM, Papp
JR, Markowitz L, Unger ER.
Abstract
We determined the prevalence of and the risk factors for human papillomavirus
(HPV) infection and abnormal cytologic test results in 312 adolescent
girls (mean age, 16.1 years). Subjects had a median of 2 years of sexual
activity and 4 lifetime sex partners. Cervical HPV was detected by use
of L1-consensus polymerase chain reaction in 64% of subjects; half of
those with HPV had >1 type, and 77% had >/=1 high-risk type. Independent
risk factors for HPV were lifetime number of sex partners, age of partner,
and douching. Cytologic abnormalities were common (20.9% of subjects
had atypical squamous cells of uncertain significance, and 17.0% had
high- or low-grade squamous intraepithelial lesions) and were significantly
associated with detection of HPV (P=.0001); however, most (51.6%) subjects
with HPV had normal cytologic test results.