AstraZeneca Letter - Regarding Supply Update For Toprol-XL® (metoprolol succinate) Bottles

March 11, 2009

Dear Distribution Partner,

AstraZeneca is pleased to advise you that we are removing the order managing process for Toprol-XL° (metoprolol succinate) bottles, effective Monday 3/16/09.

Beginning 3/16/09, the following products will be removed from the order managing process:

00186109205 TOPROL XL 100MG TABLETS 1000T BT
00186109405 TOPROL XL 200MG TABLETS 1000T BT
00186108805 TOPROL XL 25MG TABLETS 1000T BT
00186109005 TOPROL XL 50MG TABLETS 1000T BT

We appreciate your patience and understanding during the last 3 months and thank you for your cooperation. If you have any questions, please contact our AstraZeneca Account Directors or AstraZeneca Order Fulfillment at 1-800-842-9920 during the hours of 8:00 am to 5:00 pm Monday – Friday, Eastern Standard Time.

Sincerely,

/S/ John Callahan
Sr. Manager, Order Fulfillment