Keith Shockley, Ph.D., is interested in using genetic and environmental data to improve toxicity testing. He assists members of the National Toxicology Program (NTP) to identify genes that control biological responses to environmental exposures, analyzes and interprets biological response data from high throughput screening assays, and scrutinizes gene expression data from large scale microarray studies. He has recently become interested in using chemoinformatics approaches to support chemical nominations and biomolecular screening, and in constructing genetic models to predict human toxicity.
Shockley received his B.S. in chemical engineering from New Mexico State University in 1998, and his M.S. and Ph.D. in chemical engineering from North Carolina State University in 2000 and 2004, respectively.
Selected Publications
Shockley, K. R., Lazarenko, O. P., Czernik, P. J., Rosen, C. J., Churchill, G. A. & Lecka-Czernik, B. (2009). PPAR-gamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. Journal of Cellular Biochemistry. 106: 232-246. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/19115254?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Ackert-Bicknell, C. L., Shockley, K. R., Horton, L. G., Lecka-Czernik, B., Churchill, G. A. & Rosen, C. J. Strain specific effects of Rosiglitazone on bone mass, body composition and serum IGF-1. Endocrinol 2009; 150:1330-1340. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/18948404?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Stylianou, I. M., Affourtit, J. P., Shockley, K. R., Abdi, F. A., Sanjeev, B., Rollins, J.,Churchill, G. A., & Paigen, B. A. (2008). Applying gene expression, proteomics and SNP analysis for complex trait gene identification. Genetics. 178: 1795-1805. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/18245842?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Chou, C. J.-, Shockley, K. R., Conners, S. B., Lewis, D. L., Comfort, D. A., Adams, M. W. W. & Kelly, R. M. (2007). Impact of substrate glycoside linkage and elemental sulfur on bioenergetics of and hydrogen production by the hyperthermophilic archaeon Pyrococcus furiosus. Applied and Environmental Microbiology. Applied and Environmental Microbiology. 73: 6842-6853. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17827328?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Mackiewicz, M., Shockley, K. R., Romer, R., Galante, R., Zimmerman, J. E., Nadoo, N., Baldwin, D., Churchill, G. A. & Pack, A. I. (2007). Macromolecule biosynthesis — a key function of sleep. Physiological Genomics. Physiological Genomics. 31: 441-457. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17698924?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Shockley, K. R., Rosen, C. J., Churchill, G. A. & Lecka-Czernik, B. (2007). PPARgamma2 regulates a molecular signature of marrow mesenchymal stem cells. PPAR Research 81219. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/18288266?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Lecka-Czernik, B., Ackert-Bicknell, C., Adamo, M. L., Marmejelos , V., Churchill, G. A., Shockley, K. R., Reid, I., Gray, A. & Rosen, C.J. (2007). Activation of peroxisome proliferator-activated receptor γ?(PPARγ) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology. 148: 903-911. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17122083?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Madding, L. S., Michel, J. K., Shockley, K. R., Conners, S. B., Epting, K. L., Johnson, M. R. & Kelly, R. M. (2007). Role of the β1 subunit in the function and stability of the 20S proteasome in the hyperthermophilic archaeon Pyrococcus furiosus. Journal of Bacteriology. 189: 583-590. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/17114253?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Zimmerman, J. E., Rizzo, W., Shockley, K. R., Raizen, D. M., Mackiewicz, M., Churchill, G. A. & Pack, A. I. (2006). Multiple mechanisms limit the duration of wakefulness in Drosophila brain. Physiological Genomics. 27: 337-350. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16954408?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Cui, X., Affoutit, J., Shockley, K. R., Woo, Y. & Churchill, G. A. (2006). Inheritance patterns of transcript levels in F1 hybrid mice. Genetics. 174: 627-637. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16888332?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Li, R., WernTsaih, S., Shockley, K., Stylianou, I. M., Wergedal, J., Paigen, B. & Churchill, G. A. (2006). Structural model analysis of multiple quantitative traits. PLoS Genetics. 2: e114.
Shockley, K. R. & Churchill, G.A. (2006). Gene expression analysis of mouse chromosome substitution strains. Mammalian Genome. 17: 598-614. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16783641?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Lee, H.- S., Shockley, K. R., Schut, G. J., Conners, S. B., Montero, C. I., Johnson, M. R., Chou, C.- J., Bridger, S. L., Wigner, N., Brehm, S. D., Jenney, Jr., F. E., Comfort, D. A., Kelly, R. M., & Adams, M. W. W. (2006). Transcriptional and biochemical analysis of starch metabolism in the hyperthermophilic archaeon Pyrococcus furiosus. Journal of Bacteriology. 188: 2115-2125. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16513741?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Johnson, M. R., Conners, S. B., Montero, C. I., Chou, C. J., Shockley, K. R. & Kelly, R. M. (2006). The Thermotoga maritima phenotype is impacted by syntrophic interaction with Methanococcus jannaschii in hyperthermophilic coculture. Applied and Environmental Microbiology. 72: 811-818. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/16391122?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Book Chapters and Review Articles
Mackiewicz, M., Zimmerman, J., Shockley, K. R., Churchill, G. A. & Pack, A. I. What are microarrays teaching us about sleep? (2009). Trends in Molecular Medicine. 15: 79-87. [Abstract](http://www.ncbi.nlm.nih.gov/pubmed/19162550?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Tachdjian, S., Shockley, K. R., Conners, S. B. & Kelly, R. M. (2008). Functional genomics of stress response in extremophilic archaea. In P. Blum (ed.), Archaea: New Models for Prokaryotic Biology. Caister Academic Press, Wymondham, UK.
Adams, M. W. W., Jenney, F. E., Chou, C. —J., Hamilton-Brehm, S., Poole, F. L., Shockley, K. R., Tachdijian, S., & Kelly, R. M. (2006). Transcriptomics, proteomics and structural genomics of Pyrococcus furiosus. Archaea — physiology, molecular biology and evolution. In Garrett, R. and Klenk, R.- P. (eds.), Archaea. Blackwell Publishing Inc., Malden, Massachusetts.
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