Technology for Structural Biology - National Center for Research Resources

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Research Resources
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Twelve Biomedical Technology Research Centers (BTRCs) are supported in the broad area of Structural Biology to develop technologies for studying the structures of biomolecules in the size range of peptides to cells using nuclear magnetic resonance (NMR), synchrotron radiation and multiple types of microscopy. A combined goal of Structural Biology and Systems Biology areas is to understand the functions and mechanisms of important biological molecules in their various forms and in the different places they show up in the cell throughout the cell cycle.

The National Center for Research Resources and the National Institute of General Medical Sciences convened a working group on April 27–28, 2008, to advise us on the capabilities of and capacity needed for life sciences research at the National Synchrotron Light Source-II (NSLS-II). NSLS-II is a new Department of Energy synchrotron facility to be built over the next several years, replacing the current NSLS, and is scheduled to become fully operational in 2015. The panel has issued a report. READ MORE >>

Resource Centers

BioCARS: A Synchrotron Structural Biology Resource
Principal Investigator: Keith Moffat, Ph.D.
synchrotron center for macromolecular crystallography READ MORE >>

Biophysics Collaborative Access Team
Principal Investigator: Thomas Irving, Ph.D.
x-ray scattering using synchrotron radiation to study macromolecular structure READ MORE >>

Macromolecular Crystallography at the National Synchrotron Light Source
Principal Investigator: Robert M. Sweet, Ph.D.
synchrotron center for macromolecular crystallography READ MORE >>

Macromolecular Diffraction Biotechnology Resource
Principal Investigator: Richard A. Cerione, Ph.D.
synchrotron center for macromolecular crystallography READ MORE >>

National Biomedical Center for Advanced ESR Technology
Principal Investigator: Jack H. Freed, Ph.D.
electron spin resonance technology READ MORE >>

National Magnetic Resonance Facility at Madison
Principal Investigator: John L. Markley, Ph.D.
nuclear magnetic resonance spectroscopy READ MORE >>

National Resource for Automated Molecular Microscopy
Principal Investigator: Bridget Carragher
electron microscopy at the molecular level READ MORE >>

Synchrotron Radiation Structural Biology Resource
Principal Investigator: Keith O. Hodgson, Ph.D.
synchrotron center for macromolecular crystallography READ MORE >>

Three-Dimensional Electron Microscopy of Macromolecules
Principal Investigator: Wah Chiu, Ph.D.
CryoEM at subnanometer resolution READ MORE >>

Three-Dimensional Fine Structure of Cells and Tissues
Principal Investigator: Andreas Hoenger, Ph.D.
electron microscopy at the cellular level READ MORE >>

Undulator Resource for Structural Biology
Principal Investigator: Steven E. Ealick, Ph.D.
synchrotron center for macromolecular crystallography READ MORE >>

Visualization of Biological Complexity Resource
Principal Investigator: Carmen A. Mannella, Ph.D.
electron microscopy at the molecular level READ MORE >>

Contact Information

For further information about NCRR support for Technology for Structural Biology centers, contact:

Amy L. Swain, Ph.D.
Division of Biomedical Technology
National Center for Research Resources
National Institutes of Health
One Democracy Plaza, Room 962
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)
Telephone: 301-435-0755
Fax: 301-480-3659
E-mail: SwainA@mail.nih.gov