UT-Heart: Whole Organ Simulations Elucidate Healthy Heart Function and Help Understand Disease Conditions |
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| Launch in standalone player | |
| Air date: | Tuesday, March 17, 2009, 10:00:00 AM |
| Category: | Systems Biology |
| Description: | Systems Biology Speaker Series
To promote our understanding of the normal and abnormal function of the heart by integrating our knowledge collected at the molecular and the cellular levels, we have developed a multi-scale and multi-physics computer simulation of the heart. This simulator is based on the finite element method and consists of approximately 0.6 million elements for mechanical computation and 20 million elements for electrophysiology and incorporates mathematical models of cardiac excitation-contraction processes in each element. Its morphology is based on multi-detector CT data and has both ventricles and atria with aortic arch. In our model, fiber orientation was mapped and the conduction system was modeled with characteristic electrophysiology. Upon stimulation applied to the pacemaker site, excitation propagates to the adjacent elements resulting in the synchronous contraction and relaxation of the heart. In addition, because the fluid part representing the blood was also modeled and solved simultaneously with the structural part we can reproduce the blood flow in the atria, ventricles and aorta. Such features of the simulator enable us to extract various data and present them as we do in the clinical laboratories. These data includes ECG, UCG, Doppler ECG, Magneto-cardiogram etc. In the presentation, we will show some preliminary data generated with a diseased heart model. http://www.sml.k.u-tokyo.ac.jp/en/report/report01a.html http://www.nih.gov/sigs/sysbio |
| Author: | Seiryo Sugiura, University of Tokyo |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 14978 |
| CIT Live ID: | 7567 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14978 |