Making the Blastocyst: Linking cell Behaviour with Cell Fate |
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| Air date: | Wednesday, March 04, 2009, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | Dr. Rossant has been recognized for her contributions to science with many awards, including the Killam Prize for Health Sciences, the March of Dimes Prize in Developmental Biology, the Conklin Medal from the Society for Developmental Biology, and the CIHR Michael Smith Prize in Health Research, Canada’s most prestigious health research award. She is a fellow of both the Royal Societies of London and Canada, and holds the Lombard Insurance chair in pediatric research at SickKids.
Dr. Rossant is a founding member and serves as Deputy Scientific Director of The Stem Cell Network. She also directs the Centre for Modelling Human Disease in Toronto, which is undertaking genome-wide mutagenesis in mice to develop new mouse models of human disease. She serves on the Governing Council of the Canadian Institutes of Health Research, and chaired the Institutes’ Working Group on stem cell research. Dr. Rossant is a respected voice in the stem cell debate; she was involved with the National Academies of Science report on stem cell guidelines in the United States, and served on the International Society for Stem Cell Research (SSCR) task force charged with developing guidelines addressing the international diversity of cultural, political, legal and religious perspectives. Dr. Rossant has twice been named a Howard Hughes Medical Institute International Scholar. From Dr. Rossant: “The mouse blastocyst contains about 100 cells and only three distinct cell types. One cell type, the epiblast, gives rise to all cell types of the body and to pluripotent embryonic stem cells, while the other two cell types give rise to placental and other support cells and cell lines. By studying both the embryo and its derived stem cells, we have been able to identify some of the key transcription factors specifying cell fate in both situations and used this information to derive new endoderm progenitor cell lines from human embryonic stem cells. But only by studying the embryo itself can we discover how cell behavior in the early developing embryo leads to restriction of cell fate by the blastocyst stage. I will describe our current model for blastocyst formation which implicates cell polarity, cell position and cell sorting in the final assembly of the organized blastocyst.” The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Author: | Janet Rossant |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 14938 |
| CIT Live ID: | 7035 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14938 |
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Enhanced Audio Podcast | 1:05:16 |
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Enhanced Video Podcast | 1:05:16 | |