Tumor Stroma & The Immune Response |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Wednesday, March 25, 2009, 4:15:00 PM |
| Category: | Immunology |
| Description: | Hans Schreiber has been doing cutting edge work on tumor immunology since the early '80s. Throughout his carrier he has worked to identify the antigenic components of cancer cells and how tumor specific CD8 cells can influence and change tumor immunogenicity. The main focus and novelty of his work, however, is on the role of the tumor stroma in tumor protection as well as tumor rejection by the immune system. Early in the '90s he observed that tumors given as tissues with their established stroma were more difficult to reject than tumor cells given in suspension and that an established subcutaneous tumor was not rejected while a skin graft was, even though both carried the same antigen and were in the same mouse; suggesting a tumor-protected role for the stromal cells. Recently, he found that increasing antigen cross-presentation by tumor stromal cells makes the tumor susceptible to rejection by tumor specific CD8 cells. His talk will focus on the idea that, for optimal tumor rejection, we not only have to attack the tumor cells but also the "normal" stromal cells, and he will dissect the mechanisms of such rejection. His work will change the way we think about how CD8 cells reject tumors. He is a good and energetic speaker with a challenging and engaging personality.
For more information, visit The Immunology Interest Group |
| Author: | Hans Schreiber, MD, PhD |
| Runtime: | 75 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 14997 |
| CIT Live ID: | 7453 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14997 |