The 2002 Grantees Meeting for the HIV RFA Programs
Etiology of Cardiovascular Complications of HIV
Infection Endothelial Dysfunction in HIV Infection Cardiovascular
Complications from Cocaine Abuse in HIV Infection Genesis of Cardiomyopathy
with HIV Infection and Alcohol Abuse May 2-3,
2002 Sponsored by National
Heart, Lung, and Blood Institute National Institute on Drug Abuse
National Institutes of Health
Meeting
Summary Agenda Roster
Meeting Summary |
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This meeting was planned, organized and conducted by
Lan-Hsiang Wang, Ph.D., of the National Heart, Lung, and Blood Institute and
Jag H. Khalsa, Ph.D., of the Center on AIDS and Other Medical Consequences of
Drug Abuse (CAMCODA), within the National Institute on Drug Abuse, NIH. A group
of nationally and internationally recognized clinicians and scientists,
supported by the NHLBI and NIDA, presented and discussed:
- Current data on the etiology and underlying
pathophysiology of cardiovascular complications of HIV/AIDS, substance abuse
(cocaine, alcohol), and HIV infection
- In vitro tests and in vivo models for
the study of cardiovascular complications (e.g., cardiomyopathy) of HIV and
substance abuse
- Endothelial function in HIV infection
- The problems of design and conducting such studies
in clinical populations
Finally, the attendees made recommendations for future
research. The recommendations included the study of:
- The role of covariates in HIV-related
cardiovascular complications
- Role of other pathogens in HIV-related
cardiovascular complications
- Autoimmune mechanisms in HIV-related cardiac
conditions, particularly in combination with other pathogens
- Genetic predisposition for transition to dilated
cardiomyopathy
- Incidence, prevalence, and pathophysiology of
HIV-related cardiovascular disease in other vulnerable populations such as
women, infants, and older individuals exposed to HIV and substance abuse
- Influence of other conditions such as diabetes,
atherosclerosis, as well as lifestyle and behavior choices such as smoking and
recreational drug abuse on HIV-related cardiovascular complications
- Mechanisms of cellular injury in HIV-related
cardiovascular complications
- Interactions of viral replication, immune system
activation, inflammatory pathways, and reactive oxygen species in HIV-related
cardiovascular complications
- Metabolic/energetic mechanisms such as the role of
mitochondrial ATP production, cardiac myocyte energetics, increased reactive
oxygen species, altered oxygen utilization, and changes in gene expression in
HIV-related cardiovascular complications
- Role of highly active antiretroviral therapies
(HAART) in HIV-related cardiovascular complications
- Pharmacokinetic drug interactions between HAART and
pharmaceuticals use in the treatment of cardiac disease
- Interactions between immune cell (infected and/or
uninfected) and cardiac myocytes and their effects on recruitment mechanisms,
gene expression alterations, and cell-cell signaling events
- Role of hypothalamic-pituitary-adrenal axis in HIV
progression and HIV-related cardiovascular complications
- Pre-clinical investigations for therapies for
HIV/AIDS-related cardiovascular complications
- Animal models for studying the effects of
antiretroviral and immunorestorative therapies on HIV-related cardiovascular
complications
- Animal models for testing optimal therapies for the
treatment of HIV-related cardiovascular complications
- Therapeutics and prevention trials for
HIV/AIDS-related cardiovascular complications
- Optimal therapies for treating HIV-related
cardiomyopathy considering whether these therapies should be different from
other forms of cardiomyopathy
- Possibility and advantage of early intervention for
HIV-related cardiovascular complications
- Alternative therapies (e.g., anti-oxidants,
immunomodulators, nutritional therapies) for HIV-related cardiovascular
complications
Agenda |
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Thursday, May 2,
2002
8:00 a.m. |
Registration |
8:30
a.m. |
Welcome
and Introduction Lan-Hsiang Wang, NHLBI Jag H. Khalsa, NIDA
Hannah H. Peavy, NHLBI Sandra Colombini Hatch, NHLBI |
8:44
a.m. |
Lance
Terada (1) University of Texas Southwestern Effect of HIV Tat on
Endothelial Cell Function |
9:00
a.m. |
Mitchell
Finkel (16) West Virginia University P38 MAP Kinase Regulates
Negative Inotropic Effect of HIV gp120 on Cardiac Myocytes through Troponin I
Phosphorylation |
9:20
a.m. |
Jian-Feng
Wang (3) Beth Israel Deaconess Medical Center Functional Studies of
HIV-Tat Effects on Endothelium |
9:40
a.m. |
Winnie
Henderson (4) Oregon Health Sciences University HIV-1 vpu and tat
Modulate Endothelial Cell-B Lymphoma Cell Interactions: Implications for
AIDS-Associated Non-Hodgkin's Lymphoma |
10:00 a.m. |
Break |
10:20 a.m. |
John Ho (5)
Cornell University HIV-1 Activates Innate Immune Cells via Toll-Like
Receptor 2 |
10:40 a.m. |
Emily D.
Overholser (6) Johns Hopkins University Mechanisms of Endothelial
Cell Dysfunction in SIV Infection |
11:00 a.m. |
Lingjun Zhao
(7) Saint Louis University Medical Center Regulation of Myosin Light
Chain Phosphorylation by HIV-1 Vpr |
11:20 a.m. |
Changyi Chen
(8) Baylor College of Medicine HIV-1 gp120 Down-Regulates Endothelial
Nitric Oxide Synthase (eNOS) Expression in Human Endothelial Cells |
11:40 a.m. |
Kwang Sik Kim
(9) Johns Hopkins University Gp120 Induces Cytotoxicity of Human Brain
Microvascular Endothelial Cells |
12:00 noon |
Lunch |
1:00
p.m. |
Poster
Session (Atrium) Posters will be displayed from 8:30 a.m. until 5 p.m.
Poster presenters with odd numbers will be present from 1 p.m. to 1:50 p.m.
Poster presenters with even numbers will be present from 1:50 p.m. to 2:40 p.m.
Harris McFerrin (2)--poster presentation
only Tulane University Molecular Mechanism of Tat-Induced
Angiogenesis |
2:40 p.m. |
Break |
3:00
p.m. |
Douglas
Larson (10) University of Arizona Dilated Cardiomyopathy in Murine
Acquired Immunodeficiency Syndrome (MAIDS) |
3:20
p.m. |
Ronald
Watson (11) University of Arizona Selenium Supplementation
Decreases Coxsackievirus Heart Disease During Murine AIDS |
3:40
p.m. |
J. Bruce
Sundstrom (12) Emory University An in vitro Model for Investigating
the Role of Mast Cells in Mechanisms of Increased Fibrosis Associated with
AIDS-Related Cardiomyopathies |
4:00 p.m. |
Debasis Mondal
(13) Tulane University Synergistic Effects of Cocaine and the
Inflammatory Cytokines in Modulating Vascular Endothelial Cell Function
|
4:20
p.m. |
Guha
Krishnaswamy (14) East Tennessee State University Role of the
Inflammatory Network in Cocaine and HIV-Mediated Atherogenesis |
4:40
p.m. |
Shenghan
Lai (17) Johns Hopkins University Association of Cocaine Use With
Coronary Calcification in Injecting Drug Users in Baltimore |
5:00
p.m. |
Recommendations for Future Directions Ronald Watson |
5:20 p.m. |
Conclusion of Today's
Program |
Friday, May 3, 2000
8:30 a.m. |
Milan Fiala
(15) University of California Los Angeles (A) Human Immunodeficiency
Virus Type 1 Enters Brain and Coronary Endothelia by Macropinocytosis Dependent
upon Lipid Rafts. (B) Cocaine Binds to a G-Protein Coupled Receptor,
Signals and Restructures Coronary Artery Endothelial Cells. |
8:50 a.m. |
John Bauer
(18) Ohio State University Cocaine Induced Cardiotoxicity in Mice |
9:10 a.m. |
Roy Sutliff
(19) Emory University Cocaine Administration Increases LV Mass in HIV-1
Transgenic Mice |
9:30 a.m. |
Sonia Flores
(20) University of Colorado Evidence of Inflammation in
Tat-Transgenic Mice |
9:50 a.m.
|
John
Bauer (21) Ohio State University Mechanistic Studies of Retrovirus
Related Cardiac Dysfunction: the Murine AIDS Model and Human HIV Infection |
10:10
a.m. |
Douglas
Wallace (22) Emory University Ethanol and AIDS Cardiomyopathy: A
Mitochondrial Connection? |
10:30
a.m. |
Break |
10:50
a.m. |
Paul
Jolicoeur (23) Clinical Research Institute of Montreal Studies of
Cardiac Disease in HIV-1 Transgenic Mice |
11:10 a.m.
. |
William
Lewis (24) Emory University Combined Antiretroviral Therapy Causes
Cardiomyopathy and Elevates Plasma Lactate in Transgenic AIDS Mice |
11:30
a.m. |
Richard
Shannon (25) New England Regional Primate Research Center Cellular
Pathways Involved in Myocardial Injury in Simian AIDS: Role of Cytokines,
Inducible Nitric Oxide, and CD95 |
11:50 a.m. |
Milan Fiala
(26) University of California Los Angeles HIV-1 Envelope Protein gp120
Induces Cardiomyocyte Apoptosis and Is Associated with HIV-1
Cardiomyopathy |
12:10 p.m. |
Neil Bowles
(27) Baylor College of Medicine The Pathogenesis of Heart Disease in
HIV-Infected Children |
12:30
p.m. |
Closing
Remarks |
12:40 p.m. |
Adjournment of
Meeting |
Roster |
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Aftab A. Ansari, Ph.D.
Departments of Pathology and Laboratory Medicine Winship Cancer Center,
Room B4107 Emory University School of Medicine 1365B Clifton Road
Atlanta, GA 30322 pathaaa@emory.edu |
Sheila A. Barber, Ph.D.
Assistant Professor Division of Comparative Medicine Johns Hopkins
University School of Medicine Jefferson Street Building, Room 3-127 600
North Wolfe Street Baltimore, MD 21287
sabarber@jhmi.edu |
John A. Bauer, Ph.D. Center
for Developmental Pharmacology and Toxicology Children's Research
Institute 700 Children's Drive Columbus, OH 43205
BauerJ@pediatrics.ohio-state.edu |
Neil E. Bowles, Ph.D.
Assistant Professor Section of Cardiology Department of Pediatrics
Baylor College of Medicine Room 333E 1 Baylor Plaza Houston, TX
77030 nbowles@bcm.tmc.edu |
Changyi J. Chen, M.D., Ph.D.
Professor of Surgery Michael E. DeBakey Department of Surgery Baylor
College of Medicine 6550 Fannin, SM 1661 Houston, TX 77030
jchen@bcm.tmc.edu |
Adela Cota-Gomez, Ph.D.
Webb-Waring Institute Health Sciences Center Box C321 4200 East
Ninth Avenue Denver, CO 80262
adela.cota-gomez@uchsc.edu |
Milan Fiala, M.D.
Cardiovascular Research Lab UCLA, 3645 MRL 675 Charles Young Drive
South Los Angeles, CA 90095-1760 fiala@ucla.edu |
Mitchell S. Finkel, M.D. FACP,
FACC Professor and Vice-Chairman Department of Medicine
Professor of Physiology and Pharmacology West Virginia University
Cardiology Medical Center Drive Morgantown, WV 26506-9157
mfinkel@hsc.wvu.edu |
Sonia Flores, Ph.D.
Webb-Waring Institute Health Sciences Center University of Colorado
4200 E Ninth Ave., Box C321 Denver, CO 80262
SONIA.FLORES@UCHSC.EDU |
Jerome E. Groopman, M.D.
Professor of Medicine HIM Building, Room 351 Harvard Medical School
4 Blackfan Circle Boston, MA 02115
jgroopma@caregroup.harvard.edu
|
Sandra Colombini Hatch, M.D.
Division of Lung Diseases National Heart, Lung, and Blood Institute Two
Rockledge Center, Room 10124 6701 Rockledge Drive, MSC 7952 Bethesda,
MD 20892-7952 hatchs@nhlbi.nih.gov |
Winnie W. Henderson, M.S.
Department of Molecular Microbiology and Immunology Basic Sciences
Building, Room 6564 Oregon Health Sciences University Mail Code
L220 3181 SW Sam Jackson Park Road Portland, OR 97201
hendersw@ohsu.edu |
John L. Ho, M.D. Weill
College of Medicine Cornell University Visiting Scientist Aaron
Diamond AIDS Research Center Room 711 455 First Avenue New York, NY
10016 jlho@adarc.adarc.org |
Paul Jolicoeur, M.D., Ph.D.
Laboratory of Molecular Biology Department of Microbiology and
Immunology Clinical Research Institute of Montreal 110 Avenue des Pins,
Ouest Montréal, Québec, Canada H2W 1R7
jolicop@ircm.qc.ca |
Jag H. Khalsa, Ph.D. Health
Scientist Administrator Center on AIDS and Other Medical Consequences of
Drug Abuse National Institute on Drug Abuse National Institutes of
Health Neuroscience Center, Room 5198 MSC 9593 6001 Executive
Boulevard Bethesda, MD 20892-9593 jk98p@nih.gov |
Kwang Sik Kim, M.D. Pediatric
Infectious Diseases Johns Hopkins University School of Medicine 600
North Wolfe Street, Park 256 Baltimore, MD 21287
kwangkim@jhmi.edu |
Guha Krishnaswamy, M.D.
Department of Medicine East Tennessee State University Johnson City, TN
37614-0622 krishnas@ACCESS.ETSU.EDU |
Shenghan Lai, M.D.
Epidemiology, E6141 Johns Hopkins 615 North Wolfe Street Baltimore,
MD 21205 shlai@jhsph.edu |
Douglas F. Larson, Ph.D.
School of Medicine University of Arizona Tucson, AZ 85724
dflarson@u.arizona.edu |
William Lewis, M.D. Department
of Pathology Room 7117 WMRB Emory University School of Medicine
1639 Pierce Drive Atlanta, GA 30322 wlewis@emory.edu |
|
Joao Lima, M.D. Cardiology
Division Department of Medicine School of Medicine Johns Hopkins
University 600 North Wolfe Street Baltimore, MD 21287
jlima@jhmi.edu |
Kai Liu, M.D. Department of
Medicine East Tennessee State University James H. Quillen College of
Medicine Box 70622 Johnson City, TN 37614-0622
liuk@access.etsu.edu |
Harris McFerrin, M.S.
Microbiology Department Room 5704, Box SL-38 Tulane University 1430
Tulane Avenue New Orleans, LA 70112
Mharris1@tulane.edu |
Michael J. Mihm, Ph.D.
Division of Pharmacology College of Pharmacy The Ohio State
University 411 Riffe Building 500 West 12th Avenue Columbus, OH
43210 mihm.2@osu.edu |
Debasis Mondal, Ph.D.
Department of Pharmacology Tulane University School of Medicine New
Orleans, LA 70112 dmondal@tulane.edu |
Ashlee Moses, Ph.D. Vaccine
and Gene Therapy Institute Oregon Health Sciences University 505 NW
185th Avenue Beaverton, OR 97006 mosesa@ohsu.edu |
Emily Overholser, B.S.
Division of Comparative Medicine Johns Hopkins University Jefferson
Street Building, Room 3-127 600 North Wolfe Street Baltimore, MD
21287 eoverhol@mail.jhmi.edu
|
Pierre Paradis, Ph.D. Institut
de Recherches Cliniques de Montreal 110 avenue de Pins Ouest
Montreal, Quebec Canada, H2W 1R7
Pierre_Paradis@ircm.qc.ca |
Lisa Parvis, B.S. Division of
Comparative Medicine Johns Hopkins University Jefferson Street
Building, Room 3-127 600 North Wolfe Street Baltimore, MD 21287
lmp@hotmail.com |
Hannah H. Peavy, M.D. AIDS/TB
Scientific Research Group Lung Biology and Disease Program Division of
Lung Diseases National Heart, Lung, and Blood Institute Two Rockledge
Centre, Suite 10018 6701 Rockledge Drive, MSC 7952 Bethesda, MD
20892-7952 PeavyH@NHLBI.NIH.GOV
|
Scott Raidel, M.S. Department
of Pathology Room 7117 WMRB Emory University School of Medicine
1639 Pierce Drive Atlanta, GA 30322 sraidel@emory.edu |
Richard P. Shannon, M.D. Department
of Medicine Alletheny General Hospital 320 East North Avenue
Pittsburgh, PA 15212 RSHANNON@wpahs.org |
J. Bruce Sundstrom, Ph.D.
Department of Pathology and Laboratory Medicine Emory University School
of Medicine Winship Cancer Center, Room B4337 1365B Clifton Road
Atlanta, GA 30322 jsundst@emory.edu
|
Roy Sutliff, Ph.D. Department
of Pathology Room 7117 WMRB Emory University School of Medicine
1639 Pierce Drive Atlanta, GA 30322 rsutlif@emory.edu |
Lance S. Terada, M.D.
University of Texas Southwestern, and The Dallas Veterans Affairs Medical
Center Mail Code 151 4500 South Lancaster Dallas, TX 75216
Lance.Terada@med.va.gov |
Douglas C. Wallace, Ph.D.
Center for Molecular Medicine Emory University School of Medicine 1462
Clifton Road, Room 420 Atlanta, GA 30322
dwallace@Gen.Emory.Edu |
Jian-Feng Wang, Ph.D. Division
of Experimental Medicine Harvard Institutes of Medicine, # 342 4
Blackfan Circle Boston, MA 02115
jwang2@caregroup.harvard.edu
|
Lan-Hsiang Wang, Ph.D.
Division of Heart and Vascular Diseases National Heart, Lung, and Blood
Institute National Institutes of Health Two Rockledge Centre, Room
9206 6701 Rockledge Drive, MSC 7940 Bethesda, MD 20892-7940
LW72F@NIH.GOV |
Khaled Zerria, Ph.D. Division of
Infectious Diseases Cornell University, Room A479 1300 York Avenue
New York, NY 10021 zerria_khaled@excite.com |
Ling-Jun Zhao, Ph.D.
Institute for Molecular Virology St. Louis University Medical Center
3681 Park Avenue St. Louis, MO 63110 zhaol@slu.edu |
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