Inherited Susceptibility for Breast Cancer Metastasis (NIH-Only) |
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| Launch in standalone player | |
| Air date: | Tuesday, April 14, 2009, 8:00:00 AM |
| Category: | NCI CCR Grand Rounds (NIH Only) |
| Description: | Dr. Hunter received his Ph.D. at the Massachusetts Institute of Technology. He completed his postdoctoral training in genomics at MIT before accepting a position at the Fox Chase Cancer Center in Philadelphia, where he was an associate member. Dr. Hunter joined the Laboratory of Population Genetics at NCI as an Investigator in 1999. Subsequently, Dr. Hunter joined the Laboratory of Cancer Biology and Genetics and is now a senior investigator where he serves as the head of the Metastasis Susceptibility Section. The primary goal of Dr. Hunter’s research is to investigate the role of inherited polymorphism in the dissemination and progression of breast cancer. His laboratory uses an approach termed “systems genetics”, a multi-disciplinary approach including genetically engineered mouse models, genome-wide analytical approaches, mouse and human association studies and in vitro and in vivo modeling. His laboratory was the first to demonstrate that breast cancer metastasis has a significant inherited component. Dr. Hunter has authored or co-authored more than 70 articles and book chapters in the fields of mouse genomics and genetics as well as inherited metastasis susceptibility.
SELECTED REFERENCES: 1. Crawford NPS, Qian X, Ziogas Ar, Boersma B, Walker RC, Papageorge AG, Lukes L, Rowe W, Zhang J, Ambs S, Lowy DR, Anton-Culver H, Hunter KW. Rrp1b, a new susceptibility gene for breast cancer progression and metastasis. PLOS Genetics 2007;3(11):2296–2311. 2. Hunter KW. Host genetics influences tumor metastasis. Nature Reviews Cancer 2006;6:141–146. 3. Park Y-G, Zhao X, Lesueur F, Lowy DR, Lancaster M, Pharoah P, Qian X, Hunter K. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Nature Genetics 2005;37:1055–1062. NCI’s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx |
| Author: | Kent W. Hunter, PhD |
| Runtime: | 60 minutes |
| CIT File ID: | 15030 |
| CIT Live ID: | 7594 |
| Permanent link: | http://videocast.nih.gov/launch.asp?15030 |