| | Principal Investigators
| Alexei Morozov, Ph. D. |
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Dr. Morozov obtained an M.S. in Biochemistry from Lomonosov Moscow State University and received Ph. D from the University of Illinois at Chicago. During postdoctoral training with Eric Kandel at Columbia University, he employed conditional genetic manipulations to study mechanisms of neuronal plasticity, learning, and memory. Dr. Morozov joined NIMH as an investigator in 2002 to establish the Unit on Behavioral Genetics |
| Research Interests |
| Fear and aggression are necessary for survival, but may become maladaptive during mental disorders. Our aim is to understand how fear and aggression are regulated at the level of specific neuronal circuits, and we approach this aim by studying mice where brain circuitry responsible for defensive behaviors is altered pharmacologically, through region-restricted mutations, or during natural development of the brain. Parallel analyses of behavioral, molecular, and synaptic changes in these models allow us to find potential targets for control of pathological aggression and fear. |
| Representative Selected Recent Publications: |
- Bing-Xing Pan, Yulin Dong, Wataru Ito, Yuchio Yanagawa, Ryuichi Shigemoto and Alexei Morozov:
Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.
Neuron, in press, 2009.
- Wataru Ito, Bing-Xing Pan, Chao Yang, Siddarth Thakur and Alexei Morozov:
Enhanced generalization of auditory conditioned fear in juvenile mice.
Learn Mem, in press, 2009.
- Pan B., Vautier, F., Ito W., Bolshakov VY and Morozov A:
Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1.
J Neurosci., Feb 27;28(9):2089-98, 2008.
- A. Morozov:
Conditional gene expression and targeting in neuroscience research.
Prot. Neurosci., 44: 4.31.1-4.31.10 , 2008.
- Nolan MF, Malleret G, Dudman JT, Buhl D, Santoro B, Gibbs E, Vronskaya S, Buzsaki G, Siegelbaum SA, Kandel ER and A Morozov:
A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons.
Cell, Nov 24;119(5):719-32., 2004.
- Morozov A, Kellendonk C, Simpson E, Tronche F:
Using conditional mutagenesis to study the brain.
Biol. Psychiatry , Dec 1; 54(11): 1125-33, 2003.
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Address:
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Dr. Alexei Morozov
Behavioral Genetics Unit, NIMH
Porter Neuroscience Research Center
Building 35, Room 1C-1016
35 Convent Dr, MSC 3711
Bethesda, MD 20892-3711 |
| Phone: |
301-451-8463 |
| Email Dr. Morozov |
| Fax: |
301-480-3107 |
| Lab Web Site: |
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