Board of Scientific Counselors
Scientific Directors Preface
Overview of the Year's Institutional Achievements
Cell Biology and Metabolism Branch Protein Trafficking in the Endosomal-Lysosomal System: Juan Bonifacino Cell Cycle Regulation in Oogenesis: Mary Lilly Roles of the Sec7 Domain ARF GTPase Exchange Factors in Membrane Trafficking: Catherine Jackson Localization and Dynamics of Intracellular Organelles: Jennifer Lippincott-Schwartz Gene Regulation in Response to Environmental Signals: Gisela Storz Regulation of Intracellular Iron Metabolism: Tracey Rouault VHL Tumor Suppressor Gene: Richard Klausner
Developmental Endocrinology Branch Growth and Metabolism: Carolyn Bondy Womens Health: Carolyn Bondy The Menstrual Cycle and Human Reproduction: Lawrence Nelson Cellular and Molecular Mechanisms of Bone Growth: Jeffrey Baron Neuroendocrinology of Stress: Greti Aguilera Growth and Obesity: Jack Yanovski Endocrine Genetics: Constantine Stratakis
Endocrinology and Reproduction Research Branch Phosphoinositide-Calcium Signaling in Cell Regulation: Tamás Balla Peptide Hormone Receptors and Signal Transduction: Kevin Catt Structure and Function of Peptide and Protein Hormones: Hao-Chia Chen Gonadal Receptors and Mechanism of Action of Peptide Hormones in Steroidogenic Cells: Maria Dufau Signal Transduction In Synaptic Transmission: Kuo-Ping Huang Intracellular Signaling in Endocrine and Neuroendocrine Cells: Stanko Stojilkovic The Biotransformation of Endobiotics bv Sulfonation: Charles Strott
Heritable Disorders Branch Connective Tissue Disorders: Joan Marini Inborn Errors of Metabolism: William Gahl Molecular Biology of Dysmorphology: Forbes Porter Molecular Genetics of Heritable Human Disorders: Janice Chou Heritable Disorders of Phospholipid Metabolism and of the Lipid Modification of Proteins: Anil Mukherjee Genetic Disorders of Drug Metabolism: Ida Owens
Laboratory of Cellular and Molecular Biophysics The Mechanism of Exocytosis: Joshua Zimmerberg Membrane Intermediates in Biological Fusion: Leonid Chernomordik Transfer of Protein from Electrophoretic Bands into Mass Spectrometry by Direct Electroelution: Andreas Chrambach Protein/Peptide Mass Spectrometry: Alfred Yergey Cell Interactions in Three-Dimensional Tissue Culture: Leonid Margolis
Laboratory of Cellular and Molecular Neurophysiology Structure and Function of Glutamate Receptors: Mark Mayer
Laboratory of Cellular and Synaptic Neurophysiology Hippocampal Interneurons and Their Role in Controlling Excitability: Chris Mcbain Regulation of Neuronal Gene Expression by Action Potentials: Douglas Fields Regulation of Glial Development in the Central Nervous System: Vittorio Gallo Neurotrophic Regulation of Synapse Development and Plasticity: Bai Lu Second Messenger Systems in Glia and Pineal Cells: James Russell
Laboratory of Comparative Ethology Genetic and Environmental Determinants of Primate Biobehavioral Development: Stephen Suomi Mechanisms Regulating Auditory Communication and Social Behavior in Primates and other Mammals: John Newman Child and Family Development in the First Two Decades of Life: Marc Bornstein Child Development in Context: Michael Lamb
Laboratory of Developmental and Molecular Immunity Vaccines Against Human Pathogenic Bacteria: John Robbins Human Immune Response to Polysaccharide-Protein Conjugate Vaccines: Rachel Schneerson
Laboratory of Developmental Neurobiology Protein Trafficking and Secretory Granule Biogenesis in Neuroendocrine Cells: Peng Loh Transcriptional Mechanisms Regulating Activity-Dependent Gene Expression: Andres Buonanno Tetanus and Botulinum Neurotoxins and Neuronal Cell Biology: Elaine Neale Activity-Dependent Selective (Hebbian) Synapse Modulation: Phillip Nelson Neuropeptide-Mediated Regulation of Development: Douglas Brenneman Dynamic Regulation of the Melatonin Rhythm Enzyme: David Klein
Laboratory of Gene Regulation and Development Analysis of the S-Phase Checkpoint in Higher Eukaryotes: Mary Dasso Mechanism and Regulation of Eukaryotic Protein Synthesis: Thomas Dever Transcriptional and Translational Regulatory Mechanisms in Nutrient Control of Gene Expression: Alan Hinnebusch Epigenetic Gene Silencing: Rohinton Kamakaka Molecular Genetics of Retrotransposons: Henry Levin Molecular Analysis of Frog Metamorphosis: Yun-Bo Shi The Role of Smc-Family Proteins and Associated Factors in Chromosome Segregation: Alexander Strunnikov
Laboratory of Integrative and Medical Biophysics Cell Biophysics: Ralph Nossal Medical Biophysics: Robert F Bonner Quantitative Optical Imaging and Spectroscopy: Amir Gandjbakhche Tissue Biophysics and Biomimetics: Peter Basser
Laboratory of Mammalian Genes and Development Genes That Fashion the Mouse Embryo: Heiner Westphal Signals Regulating T Cell Development: Paul Love Molecular Genetics of an Imprinted Gene Cluster on Mouse Distal Chromosome 7: Karl Pfeifer
Laboratory of Molecular Genetics Molecular Genetics of Embryogenesis in Xenopus And Zebrafish: Igor Dawid Regulation of Spatial Organization and Terminal Differentiation in Vertebrate Embryos: Thomas Sargent Vertebrate Neural Development: Ajay Chitnis The Formation of the Vascular System in Zebrafish: Brant Weinstein Control of Gene Expression During Development: Judith Kassis Regulation of Homeotic Genes in Drosophila: James Kennison Integrative Control of Macromolecular Synthesis: Michael Cashel Use of RNA-DNA Hybrids for Replication and Repair of DNA and as Drug Therapy: Robert Crouch Molecular Genetics of Mammlian Retrovirus Replication: Judith G. Levin The Mechanism and Control of Transciption Termination: Robert Weisberg
Laboratory of Molecular Growth Regulation Developmental Gene Regulation of the Immune System: Keiko Ozato Mechanisms of Eukaryotic RNA Expression and Functions of the Human La Antigen: Richard Maraia Gene Expression at the Beginning of Mammalian Development: Melvin Depamphilis Control of Mammalian Cell Proliferation: Bruce Howard
The Laboratory of Physical and Structural Biology Physical Forces Organizing Biomolecules: Adrian Parsegian Direct Measurement and Computation of Forces Between Membranes or Macromolecules: Donald Rau Biophysics of Large Membrane Channels: Sergey Bezrukov Physical Principles of Biomolecular Recognition, Self-Assembly, and Regulation: Sergey Leikin
Pediatric And Reproductive Endocrinology Branch Hereditary Endocrine Disorders of the HPA Axis: George Chrousos Interactions Between the Immune System and the HPA Axis: George Chrousos Molecular Biology, Histology, Biochemistry, and Localization of Pheochromocytoma: Karel Pacak The Physiology of Hypercortisolism: Lynnette Nieman Reproductive Endocrinology and Infertility: James Segars
Perinatology Research Branch Pathophysiology of Premature Labor and Complications of Prematurity: Roberto Romero Prenatal Diagnosis of Congenital Anomalies: Roberto Romero
Section on Developmental Genomics Developmental Genomics: Wai-Yee Chan
Section on DNA Replication, Repair and Mutagenesis DNA Replication, Repair, and Mutagenesis: Roger Woodgate