Glutamate-Activated Signaling Complexes: New Insights From Genetic Analysis |
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| Launch in standalone player | |
| Air date: | Monday, May 14, 2007, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 75 minutes |
| NLM Title: | Glutamate-activated signaling complexes : new insights from genetic analysis [electronic resource] / Andres Villu Maricq. |
| Series: | NIH neuroscience seminar series |
| Author: | Maricq, Andres Villu. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | NIH neuroscience seminar series |
| Abstract: | (CIT): Glutamate is the major excitatory neurotransmitter in the brain and exerts its actions by binding to several classes of glutamate-activated receptors. Since dysfunction of glutamate-receptor-mediated signaling is implicated in various mental health and neurological disorders, there is intense interest in gaining a greater understanding of the molecules required for the assembly, localization and function of ionotropic glutamate receptors (iGluRs). In Dr. Maricq's laboratory, they have demonstrated that AMPA (GLR-1, GLR-2) and NMDA (NMR-1) subtypes of glutamate receptors contribute to specific avoidance and foraging behaviors in C. elegans . How are the function of these receptors regulated and how are they localized to synapses? Using a genetic approach they have identified a new transmembrane protein, SOL-1 that co-localizes with GLR-1 and that is absolutely required for AMPA receptor function. More recently, they have found a second transmembrane protein that is required for glutamate-gated currents. These new discoveries will help provide a mechanistic understanding of how different classes of iGluRs are distributed to and maintained at specific synapses, how they participate in synaptic communication, and how they contribute to the behavior of C. elegans. NIH Neuroscience Seminar Series. |
| Subjects: | Brain--physiology Glutamic Acid Receptors, AMPA--physiology Receptors, N-Methyl-D-Aspartate--physiology Synaptic Transmission--physiology |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WL 102.8 |
| NLM ID: | 101308578 |
| CIT File ID: | 13818 |
| CIT Live ID: | 5257 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13818 |
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Enhanced Audio Podcast | 1:12:05 |
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Enhanced Video Podcast | 1:12:05 | |